RAD51 paralog function in replicative DNA damage and tolerance.
Journal
Current opinion in genetics & development
ISSN: 1879-0380
Titre abrégé: Curr Opin Genet Dev
Pays: England
ID NLM: 9111375
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
received:
29
04
2021
revised:
22
06
2021
accepted:
23
06
2021
pubmed:
27
7
2021
medline:
5
4
2022
entrez:
26
7
2021
Statut:
ppublish
Résumé
RAD51 paralog gene mutations are observed in both hereditary breast and ovarian cancers. Classically, defects in RAD51 paralog function are associated with homologous recombination (HR) deficiency and increased genomic instability. Several recent investigative advances have enabled characterization of non-canonical RAD51 paralog function during DNA replication. Here we discuss the role of the RAD51 paralogs and their associated complexes in integrating a robust response to DNA replication stress. We highlight recent discoveries suggesting that the RAD51 paralogs complexes mediate lesion-specific tolerance of replicative stress following exposure to alkylating agents and the requirement for the Shu complex in fork restart upon fork stalling by dNTP depletion. In addition, we describe the role of the BCDX2 complex in restraining and promoting fork remodeling in response to fluctuating dNTP pools. Finally, we highlight recent work demonstrating a requirement for RAD51C in recognizing and tolerating methyl-adducts. In each scenario, RAD51 paralog complexes play a central role in lesion recognition and bypass in a replicative context. Future studies will determine how these critical functions for RAD51 paralog complexes contribute to tumorigenesis.
Identifiants
pubmed: 34311385
pii: S0959-437X(21)00080-0
doi: 10.1016/j.gde.2021.06.010
pmc: PMC8671181
mid: NIHMS1721602
pii:
doi:
Substances chimiques
DNA
9007-49-2
Rad51 Recombinase
EC 2.7.7.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
86-91Subventions
Organisme : NIEHS NIH HHS
ID : R01 ES030335
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES031796
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Références
J Biol Chem. 2003 Nov 14;278(46):45445-50
pubmed: 12966089
Cell. 1997 Sep 19;90(6):1123-35
pubmed: 9323140
Nat Commun. 2020 Jul 15;11(1):3531
pubmed: 32669601
Cell. 2015 Jul 16;162(2):271-286
pubmed: 26186187
DNA Repair (Amst). 2019 Apr;76:99-107
pubmed: 30836272
Transl Oncol. 2021 Mar;14(3):101012
pubmed: 33516088
Nucleic Acids Res. 1998 Jul 1;26(13):3084-9
pubmed: 9628903
Cell Chem Biol. 2021 Jun 17;28(6):835-847.e5
pubmed: 33662256
Oncogene. 2014 Oct 2;33(40):4803-12
pubmed: 24141787
Genes Dev. 2020 Jun 1;34(11-12):832-846
pubmed: 32354836
EMBO J. 2000 Dec 15;19(24):6675-85
pubmed: 11118202
Nat Commun. 2018 Oct 10;9(1):3961
pubmed: 30305635
Mutat Res. 1987 May;183(3):279-86
pubmed: 3106801
EMBO J. 1982;1(8):945-51
pubmed: 6329717
J Biol Chem. 2000 Jun 2;275(22):16443-9
pubmed: 10749867
Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8440-6
pubmed: 11459987
Nucleic Acids Res. 2002 Feb 15;30(4):1001-8
pubmed: 11842112
Mol Biol Cell. 2007 Oct;18(10):4062-73
pubmed: 17671161
Elife. 2021 Nov 01;10:
pubmed: 34723799
Mutat Res. 2000 Jun 30;451(1-2):39-51
pubmed: 10915864
Mol Cell. 2003 Apr;11(4):1109-17
pubmed: 12718895
Nucleic Acids Res. 2013 Apr;41(8):4525-34
pubmed: 23460207
J Biol Chem. 2011 Dec 2;286(48):41758-41766
pubmed: 21965664
Nucleic Acids Res. 2016 Dec 15;44(22):10879-10897
pubmed: 27924011
Genesis. 2000 Mar;26(3):167-73
pubmed: 10705376
Nat Commun. 2019 Aug 5;10(1):3515
pubmed: 31383866
Cell Rep. 2019 Oct 15;29(3):551-559.e4
pubmed: 31618626
PLoS Genet. 2019 Oct 4;15(10):e1008355
pubmed: 31584931
Cancer Discov. 2017 Sep;7(9):984-998
pubmed: 28588062
Mol Cell. 2021 Mar 4;81(5):1043-1057.e8
pubmed: 33421364
Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10640-5
pubmed: 23754376
Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10646-51
pubmed: 23509288
Nucleic Acids Res. 2002 May 15;30(10):2172-82
pubmed: 12000837
Genetics. 2005 Mar;169(3):1275-89
pubmed: 15654096
Nat Commun. 2019 Mar 29;10(1):1407
pubmed: 30926776
Nucleic Acids Res. 2019 Dec 16;47(22):11729-11745
pubmed: 31642493
J Biol Chem. 2002 Mar 8;277(10):8406-11
pubmed: 11744692
Nucleic Acids Res. 2015 Nov 16;43(20):9835-55
pubmed: 26354865
Nucleic Acids Res. 2016 Sep 30;44(17):8199-215
pubmed: 27298254
Mol Cell Biol. 1999 Dec;19(12):8686-93
pubmed: 10567591
Genomics. 1998 Apr 1;49(1):103-11
pubmed: 9570954
Nat Struct Mol Biol. 2018 Jun;25(6):446-453
pubmed: 29807999
Nat Commun. 2021 Jul 12;12(1):4255
pubmed: 34253720
Genetics. 2015 Apr;199(4):1023-33
pubmed: 25659377
Nucleic Acids Res. 2019 Nov 4;47(19):10151-10165
pubmed: 31665741
Mutat Res. 1988 Mar;193(2):109-21
pubmed: 3347204
Trends Genet. 1999 May;15(5):166-8
pubmed: 10322480
Genomics. 1997 Dec 15;46(3):476-9
pubmed: 9441753
Mol Cell. 2019 Jun 6;74(5):866-876
pubmed: 31173722
Genes Dev. 2001 Dec 15;15(24):3296-307
pubmed: 11751635