Gold(III) porphyrins: Synthesis and interaction with G-quadruplex DNA.
Au(3+)-complexes
Cationic porphyrins
FRET melting
G4
HIV-1
Modeling
Journal
Journal of inorganic biochemistry
ISSN: 1873-3344
Titre abrégé: J Inorg Biochem
Pays: United States
ID NLM: 7905788
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
03
03
2021
revised:
09
07
2021
accepted:
15
07
2021
pubmed:
3
8
2021
medline:
8
2
2022
entrez:
2
8
2021
Statut:
ppublish
Résumé
G-quadruplex nucleic acids (G4s) are RNA and DNA secondary structures involved in the regulation of multiple key biological processes. They can be found in telomeres, oncogene promoters, RNAs, but also in viral genomes. Due to their unique structural features, very distinct from the canonical duplexes or single-strands, G4s represent promising pharmacological targets for small molecules, namely G4-ligands. Gold(III) penta-cationic porphyrins, as specific G4 ligands, are able to inhibit HIV-1 infectivity and their antiviral activity correlates with their affinity for G4s. Up to now, one of the best antiviral compounds is meso-5,10,15,20-tetrakis[4-(N-methyl-pyridinium-2-yl)phenyl]porphyrinato gold(III) (1). Starting from this compound, we report a structure/affinity relationship study of gold(III) cationic porphyrins to find out the best porphyrin candidate for functionalization, in order to study the antiviral mechanism of action of these gold(III) porphyrins.
Identifiants
pubmed: 34340058
pii: S0162-0134(21)00198-7
doi: 10.1016/j.jinorgbio.2021.111551
pii:
doi:
Substances chimiques
Anti-HIV Agents
0
Metalloporphyrins
0
Gold
7440-57-5
DNA
9007-49-2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
111551Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.