vhp Is a Fibrinogen-Binding Protein Related to vWbp in Staphylococcus aureus.
Staphylococcus aureus
fibrinogen-binding proteins
vWbp homolog
vhp
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
31 08 2021
31 08 2021
Historique:
pubmed:
4
8
2021
medline:
1
1
2022
entrez:
3
8
2021
Statut:
ppublish
Résumé
Staphylococcus aureus can target a variety of tissues, causing life-threatening infections. The basis for this diversity stems from the microorganism's ability to spread in the vascular system throughout the body. To survive in blood, S. aureus coats itself with a fibrinogen (Fg)/fibrin shield. The protective shield is assembled by the coordinated actions of a number of Fg-binding bacterial proteins that manipulate the host's blood coagulation system. Several of the Fg binders appear redundant, sharing similar functional motifs. This observation led us to screen for the presence of novel proteins with significant amino acid identities to von Willebrand factor-binding protein (vWbp), a key component in the shield assembly machinery. One identified protein showed significant sequence identity with the C-terminal region of vWbp, and we consequently named it vWbp homologous protein (vhp). The
Identifiants
pubmed: 34340548
doi: 10.1128/mBio.01167-21
pmc: PMC8406236
doi:
Substances chimiques
Bacterial Proteins
0
Carrier Proteins
0
Virulence Factors
0
von Willebrand Factor
0
Fibrinogen
9001-32-5
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0116721Subventions
Organisme : NIAID NIH HHS
ID : R01 AI020624
Pays : United States
Organisme : NIAID NIH HHS
ID : R56 AI020624
Pays : United States
Références
FASEB J. 2009 Oct;23(10):3393-404
pubmed: 19525403
Mol Syst Biol. 2011 Oct 11;7:539
pubmed: 21988835
mBio. 2016 Jan 05;7(1):e01885-15
pubmed: 26733070
J Exp Med. 2007 Oct 1;204(10):2461-71
pubmed: 17893203
PLoS Comput Biol. 2015 Sep 14;11(9):e1004346
pubmed: 26366880
PLoS Pathog. 2013;9(12):e1003816
pubmed: 24348255
J Biol Chem. 2013 Sep 27;288(39):28283-92
pubmed: 23960083
Vaccine. 2015 Oct 5;33(41):5452-5457
pubmed: 26319743
Semin Thromb Hemost. 2016 Jun;42(4):408-21
pubmed: 27056151
PLoS Pathog. 2010 Aug 05;6(8):e1001036
pubmed: 20700445
Science. 2013 Nov 15;342(6160):863-6
pubmed: 24233725
J Thromb Haemost. 2018 Mar;16(3):441-454
pubmed: 29251820
J Exp Med. 2016 Mar 7;213(3):293-301
pubmed: 26880578
J Biol Chem. 2012 Nov 9;287(46):39149-57
pubmed: 23012355
FEMS Microbiol Lett. 2004 May 15;234(2):309-14
pubmed: 15135538
Nat Rev Microbiol. 2014 Jan;12(1):49-62
pubmed: 24336184
J Biol Chem. 2014 Jul 25;289(30):21003-21015
pubmed: 24904056
J Thromb Haemost. 2017 May;15(5):1009-1019
pubmed: 28182324
PLoS Pathog. 2011 Oct;7(10):e1002307
pubmed: 22028651
Blood. 2013 Mar 7;121(10):1783-94
pubmed: 23299312
Annu Rev Pathol. 2016 May 23;11:343-64
pubmed: 26925499
Blood Rev. 2007 May;21(3):131-42
pubmed: 17208341
J Bacteriol. 2008 Jan;190(1):447-51
pubmed: 17965149
J Bacteriol. 2005 Jun;187(11):3698-707
pubmed: 15901693
J Mol Biol. 1988 Aug 20;202(4):689-96
pubmed: 2459396
Cell Mol Life Sci. 2004 Nov;61(22):2793-8
pubmed: 15558209
J Thromb Haemost. 2005 Aug;3(8):1894-904
pubmed: 16102057
Exp Biol Med (Maywood). 2004 Dec;229(11):1105-10
pubmed: 15564436
Trends Microbiol. 1998 Dec;6(12):484-8
pubmed: 10036727
Proc Natl Acad Sci U S A. 2009 May 12;106(19):7786-91
pubmed: 19416890
PLoS One. 2008 May 21;3(5):e2206
pubmed: 18493318
Protein Sci. 1995 May;4(5):1013-6
pubmed: 7663337
PLoS Pathog. 2012 Jan;8(1):e1002434
pubmed: 22253592
Subcell Biochem. 2017;82:405-456
pubmed: 28101869
J Innate Immun. 2012;4(2):141-8
pubmed: 22222316
Nat Immunol. 2007 Apr;8(4):430-7
pubmed: 17351618
Mol Microbiol. 2010 Sep;77(6):1583-94
pubmed: 20860091
Thromb Haemost. 2018 Jul;118(7):1230-1241
pubmed: 29909601
Sci Rep. 2017 Oct 20;7(1):13665
pubmed: 29057978
J Clin Invest. 2004 Jun;113(11):1596-606
pubmed: 15173886
Arterioscler Thromb Vasc Biol. 2017 Mar;37(3):e13-e21
pubmed: 28228446
Front Cell Infect Microbiol. 2019 Apr 16;9:106
pubmed: 31041195
Infect Immun. 2012 Oct;80(10):3389-98
pubmed: 22825443
Transfus Apher Sci. 2008 Feb;38(1):15-23
pubmed: 18282807
Microbiology (Reading). 2002 Jul;148(Pt 7):2037-2044
pubmed: 12101292
Front Immunol. 2018 Jul 26;9:1731
pubmed: 30105021