Anti-inflammatory diet and venous thromboembolism: Two prospective cohort studies.
Aged
Diet
/ adverse effects
Female
Fruit
Humans
Inflammation
/ diagnosis
Male
Middle Aged
Nutritive Value
Prospective Studies
Protective Factors
Pulmonary Embolism
/ diagnostic imaging
Risk Assessment
Risk Factors
Risk Reduction Behavior
Smoking
/ adverse effects
Sweden
/ epidemiology
Vegetables
Venous Thromboembolism
/ diagnostic imaging
Venous Thrombosis
/ diagnostic imaging
Wine
Anti-inflammatory diet
Cohort
Smoking
Venous thromboembolism
Journal
Nutrition, metabolism, and cardiovascular diseases : NMCD
ISSN: 1590-3729
Titre abrégé: Nutr Metab Cardiovasc Dis
Pays: Netherlands
ID NLM: 9111474
Informations de publication
Date de publication:
22 09 2021
22 09 2021
Historique:
received:
10
06
2021
revised:
28
06
2021
accepted:
29
06
2021
pubmed:
5
8
2021
medline:
28
9
2021
entrez:
4
8
2021
Statut:
ppublish
Résumé
Inflammation has been revealed to facilitate thrombogenesis and to increase the risk of venous thromboembolism (VTE). However, limited data are available on the association between the anti-inflammatory diet and incident VTE. We conducted a cohort analysis to examine this association and to further examine whether this association is modified by smoking status, a trigger of systemic inflammation. We used data from two cohorts including 81,507 middle-aged and older Swedish adults without previous VTE at baseline. An empirically validated anti-inflammatory diet index (AIDI), based on 12 foods with anti-inflammatory potential and 5 foods with pro-inflammatory potential, was employed to estimate the anti-inflammatory potential of diet. Hazard ratios (HRs), with corresponding 95% confidence intervals (CIs), of VTE were estimated by Cox proportional hazards regression models. During a mean follow-up of 17.8-years, 5241 VTE cases were diagnosed. Compared with individuals in the lowest quartile of the AIDI (score ≤4), those in the highest quartile (score ≥8) had a 9% (95% CI, 0-17%) lower risk of VTE. The inverse association was observed in current and past smokers (HR between the two extreme quartiles, 0.80, 95% CI, 0.70-0.91) but not in never smokers (HR, 1.03, 95% CI, 0.91-1.17). French fries (HR per serving, 1.33, 95% CI, 1.06, 1.67) but no other foods included in AIDI was associated with VTE. The study suggests that a consumption of foods with high anti-inflammatory potential may play a role in the prevention of VTE in smokers.
Sections du résumé
BACKGROUND AND AIMS
Inflammation has been revealed to facilitate thrombogenesis and to increase the risk of venous thromboembolism (VTE). However, limited data are available on the association between the anti-inflammatory diet and incident VTE. We conducted a cohort analysis to examine this association and to further examine whether this association is modified by smoking status, a trigger of systemic inflammation.
METHODS AND RESULTS
We used data from two cohorts including 81,507 middle-aged and older Swedish adults without previous VTE at baseline. An empirically validated anti-inflammatory diet index (AIDI), based on 12 foods with anti-inflammatory potential and 5 foods with pro-inflammatory potential, was employed to estimate the anti-inflammatory potential of diet. Hazard ratios (HRs), with corresponding 95% confidence intervals (CIs), of VTE were estimated by Cox proportional hazards regression models. During a mean follow-up of 17.8-years, 5241 VTE cases were diagnosed. Compared with individuals in the lowest quartile of the AIDI (score ≤4), those in the highest quartile (score ≥8) had a 9% (95% CI, 0-17%) lower risk of VTE. The inverse association was observed in current and past smokers (HR between the two extreme quartiles, 0.80, 95% CI, 0.70-0.91) but not in never smokers (HR, 1.03, 95% CI, 0.91-1.17). French fries (HR per serving, 1.33, 95% CI, 1.06, 1.67) but no other foods included in AIDI was associated with VTE.
CONCLUSION
The study suggests that a consumption of foods with high anti-inflammatory potential may play a role in the prevention of VTE in smokers.
Identifiants
pubmed: 34344547
pii: S0939-4753(21)00317-3
doi: 10.1016/j.numecd.2021.06.021
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2831-2838Subventions
Organisme : CSRD VA
ID : IK2 CX001780
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest All authors declare no conflict of interest with the exception for SMD who receives research support from RenalytixAI and personal consulting fees from Calico Labs, outside the scope of the current research.