Identification of a Novel Allosteric Site at the M

Allosteric Regulation Allosteric Site Binding Sites Molecular Docking Simulation Receptor, Muscarinic M1 / genetics Receptor, Muscarinic M4 Receptors, Muscarinic / genetics
M5 muscarinic acetylcholine receptor allosteric modulation computational biology mutagenesis selectivity

Journal

ACS chemical neuroscience
ISSN: 1948-7193
Titre abrégé: ACS Chem Neurosci
Pays: United States
ID NLM: 101525337

Informations de publication

Date de publication:
18 08 2021
Historique:
pubmed: 6 8 2021
medline: 4 9 2021
entrez: 5 8 2021
Statut: ppublish

Résumé

The M

Identifiants

DOI: 10.1021/acschemneuro.1c00383 PMID: 34351123
pubmed: 34351123
doi: 10.1021/acschemneuro.1c00383
doi:

Substances chimiques

Receptor, Muscarinic M1 0
Receptor, Muscarinic M4 0
Receptors, Muscarinic 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3112-3123

Subventions

Organisme : Wellcome Trust
ID : 201529/Z/16/Z
Pays : United Kingdom

Auteurs

Wessel A C Burger (WAC)

Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
ORCID: 0000-0003-2047-2593

Patrick R Gentry (PR)

Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.

Alice E Berizzi (AE)

Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.

Ziva Vuckovic (Z)

Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.

Emma T van der Westhuizen (ET)

Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.

Geoff Thompson (G)

Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.

Mahmuda Yeasmin (M)

Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.

Craig W Lindsley (CW)

Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.
Department of Chemistry, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.
ORCID: 0000-0003-0168-1445

Patrick M Sexton (PM)

Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
ORCID: 0000-0001-8902-2473

Christopher J Langmead (CJ)

Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
ORCID: 0000-0003-3483-1120

Andrew B Tobin (AB)

The Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom.
ORCID: 0000-0002-1807-3123

Arthur Christopoulos (A)

Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.

Celine Valant (C)

Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.

David M Thal (DM)

Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
ORCID: 0000-0002-0325-2524

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Classifications MeSH

questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Régulation allostérique › Identification of a Novel Allosteric Site at the M
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Site allostérique › Identification of a Novel Allosteric Site at the M
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Identification of a Novel Allosteric Site at the M
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Identification of a Novel Allosteric Site at the M
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs cholinergiques › Récepteur muscarinique › Récepteur muscarinique de type M1 › Identification of a Novel Allosteric Site at the M
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs cholinergiques › Récepteur muscarinique › Récepteur muscarinique de type M4 › Identification of a Novel Allosteric Site at the M
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs cholinergiques › Récepteur muscarinique › Identification of a Novel Allosteric Site at the M