Identification of the transcription factor MAZ as a regulator of erythropoiesis.
Journal
Blood advances
ISSN: 2473-9537
Titre abrégé: Blood Adv
Pays: United States
ID NLM: 101698425
Informations de publication
Date de publication:
10 08 2021
10 08 2021
Historique:
received:
01
03
2021
accepted:
11
04
2021
entrez:
5
8
2021
pubmed:
6
8
2021
medline:
11
8
2021
Statut:
ppublish
Résumé
Erythropoiesis requires a combination of ubiquitous and tissue-specific transcription factors (TFs). Here, through DNA affinity purification followed by mass spectrometry, we have identified the widely expressed protein MAZ (Myc-associated zinc finger) as a TF that binds to the promoter of the erythroid-specific human α-globin gene. Genome-wide mapping in primary human erythroid cells revealed that MAZ also occupies active promoters as well as GATA1-bound enhancer elements of key erythroid genes. Consistent with an important role during erythropoiesis, knockdown of MAZ reduces α-globin expression in K562 cells and impairs differentiation in primary human erythroid cells. Genetic variants in the MAZ locus are associated with changes in clinically important human erythroid traits. Taken together, these findings reveal the zinc-finger TF MAZ to be a previously unrecognized regulator of the erythroid differentiation program.
Identifiants
pubmed: 34351390
pii: S2473-9529(21)00389-X
doi: 10.1182/bloodadvances.2021004609
pmc: PMC8361462
doi:
Substances chimiques
DNA-Binding Proteins
0
Transcription Factors
0
c-MYC-associated zinc finger protein
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3002-3015Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/J004235/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/P013732/1
Pays : United Kingdom
Organisme : Medical Research Council
Pays : United Kingdom
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2021 by The American Society of Hematology.
Références
Cancer Lett. 2016 May 28;375(1):9-19
pubmed: 26902421
Nucleic Acids Res. 2012 Sep 1;40(17):e128
pubmed: 22610855
Blood. 2016 Apr 14;127(15):1856-62
pubmed: 26903544
Epigenetics Chromatin. 2018 Oct 6;11(1):59
pubmed: 30292235
Mol Cell Biol. 2002 Feb;22(4):1027-35
pubmed: 11809795
Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21771-6
pubmed: 19959666
Nucleic Acids Res. 2008 Apr;36(6):1755-69
pubmed: 18252774
EMBO J. 2007 Apr 18;26(8):2041-51
pubmed: 17380126
Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3832-7
pubmed: 22357756
Blood. 1996 Mar 1;87(5):1793-801
pubmed: 8634425
EMBO J. 1994 Dec 1;13(23):5656-67
pubmed: 7988563
Nat Genet. 2018 Nov;50(11):1593-1599
pubmed: 30349118
J Biol Chem. 2003 Jun 20;278(25):22586-95
pubmed: 12697757
Mol Pharmacol. 2003 Nov;64(5):1180-8
pubmed: 14573768
Bioinformatics. 2011 Jun 15;27(12):1696-7
pubmed: 21486936
Mol Cell Biol. 1995 May;15(5):2437-47
pubmed: 7739528
J Biol Chem. 2010 Jul 16;285(29):22003-16
pubmed: 20457603
PLoS Genet. 2012 Sep;8(9):e1002982
pubmed: 23028375
Nucleic Acids Res. 2020 Jan 8;48(D1):D87-D92
pubmed: 31701148
Mol Cell Biol. 2008 Oct;28(20):6521-35
pubmed: 18710939
Mol Cell. 2020 Jun 4;78(5):960-974.e11
pubmed: 32330456
Epigenetics Chromatin. 2019 Jun 4;12(1):33
pubmed: 31164147
Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6454-8
pubmed: 7604012
Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12508-12
pubmed: 11070077
Blood. 2015 Mar 19;125(12):1957-67
pubmed: 25538045
Nat Biotechnol. 2008 Dec;26(12):1367-72
pubmed: 19029910
Blood Adv. 2019 Aug 27;3(16):2499-2511
pubmed: 31455666
Nat Genet. 2016 Oct;48(10):1193-203
pubmed: 27526324
Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
pubmed: 29126249
J Cell Biol. 2006 Jan 16;172(2):177-87
pubmed: 16418531
Br J Haematol. 2010 Mar;148(6):844-52
pubmed: 20096014
Nucleic Acids Res. 1991 May 11;19(9):2499
pubmed: 2041787
Nucleic Acids Res. 2014 Jan;42(1):97-108
pubmed: 24097433
Nature. 2012 Sep 6;489(7414):57-74
pubmed: 22955616
Nat Protoc. 2007;2(8):1896-906
pubmed: 17703201
Dev Cell. 2012 Oct 16;23(4):796-811
pubmed: 23041383
Eur J Haematol. 2000 May;64(5):292-303
pubmed: 10863975
BMC Mol Biol. 2014 May 16;15:8
pubmed: 24885809
Nature. 2009 May 7;459(7243):108-12
pubmed: 19295514
Blood Cells Mol Dis. 2018 May;70:2-12
pubmed: 28811072
PLoS One. 2011;6(9):e24421
pubmed: 21931711
Curr Opin Hematol. 2017 May;24(3):173-182
pubmed: 28212192
Blood. 2011 Sep 29;118(13):3684-93
pubmed: 21828133
Cold Spring Harb Perspect Med. 2013 Sep 01;3(9):a015412
pubmed: 23838521
Nat Commun. 2015 Nov 23;6:8893
pubmed: 26593974
J Biol Chem. 2001 Aug 10;276(32):30429-34
pubmed: 11395515
Dev Cell. 2016 Jan 11;36(1):9-23
pubmed: 26766440
Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):E1849-E1858
pubmed: 29432158
J Virol. 1997 Dec;71(12):9600-7
pubmed: 9371624
Blood. 2003 Aug 1;102(3):858-66
pubmed: 12676787
Genome Biol. 2007;8(2):R24
pubmed: 17324271
Biochem Biophys Res Commun. 1999 Aug 19;262(1):198-205
pubmed: 10448092
J Immunol. 2004 Apr 15;172(8):5006-15
pubmed: 15067082
Blood Cells Mol Dis. 2018 May;70:1
pubmed: 28214138
Genes Dev. 2020 Jul 1;34(13-14):950-964
pubmed: 32499402
Blood. 2005 Jan 1;105(1):85-94
pubmed: 15358620
Genes Dev. 2011 Aug 1;25(15):1583-8
pubmed: 21828268
Int J Mol Med. 2003 May;11(5):547-53
pubmed: 12684688