Trade-offs among transcription elongation rate, number, and duration of ubiquitous pauses on highly transcribed bacterial genes.

DNA-Directed RNA Polymerases / genetics Escherichia coli / genetics Genes, Bacterial Promoter Regions, Genetic Transcription, Genetic
DNA transcription average transcription rate mathematical modeling maximal elongation rate partial differential equations ribosomal genes

Journal

Journal of bioinformatics and computational biology
ISSN: 1757-6334
Titre abrégé: J Bioinform Comput Biol
Pays: Singapore
ID NLM: 101187344

Informations de publication

Date de publication:
10 2021
Historique:
pubmed: 7 8 2021
medline: 18 1 2022
entrez: 6 8 2021
Statut: ppublish

Résumé

In this paper, we study the limitations imposed on the transcription process by the presence of short ubiquitous pauses and crowding. These effects are especially pronounced in highly transcribed genes such as ribosomal genes (

Identifiants

DOI: 10.1142/S0219720021500207 PMID: 34353243
pubmed: 34353243
doi: 10.1142/S0219720021500207
doi:

Substances chimiques

DNA-Directed RNA Polymerases EC 2.7.7.6

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

2150020

Auteurs

Tomáš Gedeon (T)

Department of Mathematical Sciences, Montana State University, P.O. Box 172400, Bozeman, MT 59717-2400, USA.

Lisa Davis (L)

Department of Mathematical Sciences, Montana State University, P.O. Box 172400, Bozeman, MT 59717-2400, USA.
ORCID: 0000-0002-4613-1802

Katelyn Weber (K)

Department of Statistics, London School of Economics and Political Science, London, UK.

Jennifer Thorenson (J)

Department of Mathematics, University of Oregon, Eugene, OR, USA.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Nucleotidyltransferases › RNA nucleotidyltransferases › DNA-directed RNA polymerases › Trade-offs among transcription elongation...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › Trade-offs among transcription elongation...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Génome microbien › Génome bactérien › Gènes bactériens › Trade-offs among transcription elongation...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Éléments de régulation transcriptionnelle › Régions promotrices (génétique) › Trade-offs among transcription elongation...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Transcription génétique › Trade-offs among transcription elongation...