Syndecan Transmembrane Domain Specifically Regulates Downstream Signaling Events of the Transmembrane Receptor Cytoplasmic Domain.


Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
24 Jul 2021
Historique:
received: 30 06 2021
revised: 22 07 2021
accepted: 22 07 2021
entrez: 7 8 2021
pubmed: 8 8 2021
medline: 24 8 2021
Statut: epublish

Résumé

Despite the known importance of the transmembrane domain (TMD) of syndecan receptors in cell adhesion and signaling, the molecular basis for syndecan TMD function remains unknown. Using in vivo invertebrate models, we found that mammalian syndecan-2 rescued both the guidance defects in

Identifiants

pubmed: 34360683
pii: ijms22157918
doi: 10.3390/ijms22157918
pmc: PMC8347082
pii:
doi:

Substances chimiques

Syndecan-2 149769-25-5
src-Family Kinases EC 2.7.10.2

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : National Research Foundation of Korea
ID : 2019R1A2C2009011

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Auteurs

Jisun Hwang (J)

Department of Life Sciences, Ewha Womans University, Seoul 03760, Korea.

Bohee Jang (B)

Department of Life Sciences, Ewha Womans University, Seoul 03760, Korea.

Ayoung Kim (A)

Department of Life Sciences, Ewha Womans University, Seoul 03760, Korea.

Yejin Lee (Y)

Department of Life Sciences, Ewha Womans University, Seoul 03760, Korea.

Joonha Lee (J)

Department of Life Sciences, Korea University, Seoul 02841, Korea.

Chungho Kim (C)

Department of Life Sciences, Korea University, Seoul 02841, Korea.

Jinmahn Kim (J)

Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 42988, Korea.

Kyeong Min Moon (KM)

Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 42988, Korea.

Kyuhyung Kim (K)

Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 42988, Korea.

Ram Wagle (R)

Department of Biomedical Gerontology, Ilsong Institute of Life Science, Hallym University, Anyang-si 14066, Korea.

Young-Han Song (YH)

Department of Biomedical Gerontology, Ilsong Institute of Life Science, Hallym University, Anyang-si 14066, Korea.

Eok-Soo Oh (ES)

Department of Life Sciences, Ewha Womans University, Seoul 03760, Korea.

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Classifications MeSH