Pectins that Structurally Differ in the Distribution of Methyl-Esters Attenuate Citrobacter rodentium-Induced Colitis.
Animals
Anti-Inflammatory Agents, Non-Steroidal
/ chemistry
Cecum
/ drug effects
Citrobacter rodentium
/ pathogenicity
Citrus sinensis
/ chemistry
Colitis
/ drug therapy
Cytokines
/ metabolism
Enterobacteriaceae Infections
/ drug therapy
Esters
/ chemistry
Female
Gastrointestinal Microbiome
/ drug effects
Mice, Inbred C57BL
Pectins
/ chemistry
T-Lymphocyte Subsets
/ drug effects
Citrobacter rodentium
colitis
degree of blockiness
degree of methyl-esterification
microbiota
pectin
Journal
Molecular nutrition & food research
ISSN: 1613-4133
Titre abrégé: Mol Nutr Food Res
Pays: Germany
ID NLM: 101231818
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
revised:
29
06
2021
received:
12
04
2021
pubmed:
10
8
2021
medline:
3
3
2022
entrez:
9
8
2021
Statut:
ppublish
Résumé
Pectins have anti-inflammatory properties on intestinal immunity through direct interactions on Toll-like receptors (TLRs) in the small intestine or via stimulating microbiota-dependent effects in the large intestine. Both the degree of methyl-esterification (DM) and the distribution of methyl-esters (degree of blockiness; DB) of pectins contribute to this influence on immunity, but whether and how the DB impacts immunity through microbiota-dependent effects in the large intestine is unknown. Therefore, this study tests pectins that structurally differ in DB in a mouse model with Citrobacter rodentium induced colitis and studies the impact on the intestinal microbiota composition and associated attenuation of inflammation. Both low and high DB pectins induce a more rich and diverse microbiota composition. These pectins also lower the bacterial load of C. rodentium in cecal digesta. Through these effects, both low and high DB pectins attenuate C. rodentium induced colitis resulting in reduced intestinal damage, reduced numbers of Th1-cells, which are increased in case of C. rodentium induced colitis, and reduced levels of GATA3 Pectins prevent C. rodentium induced colonic inflammation by lowering the C. rodentium load in the caecum independently of the DB.
Identifiants
pubmed: 34369649
doi: 10.1002/mnfr.202100346
pmc: PMC9285458
doi:
Substances chimiques
Anti-Inflammatory Agents, Non-Steroidal
0
Cytokines
0
Esters
0
Pectins
89NA02M4RX
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2100346Informations de copyright
© 2021 The Authors. Molecular Nutrition & Food Research published by Wiley-VCH GmbH.
Références
Obesity (Silver Spring). 2013 Sep;21(9):E396-406
pubmed: 23696431
PLoS Pathog. 2010 May 13;6(5):e1000902
pubmed: 20485566
Nat Rev Microbiol. 2014 Sep;12(9):612-23
pubmed: 25088150
J Clin Invest. 2011 Nov;121(11):4503-15
pubmed: 21965331
Science. 2013 Aug 2;341(6145):569-73
pubmed: 23828891
Front Immunol. 2019 Jul 30;10:1733
pubmed: 31417546
Cell Microbiol. 2005 Dec;7(12):1697-706
pubmed: 16309456
Front Immunol. 2020 Jan 09;10:2976
pubmed: 31998293
Cell Metab. 2014 Nov 4;20(5):779-786
pubmed: 25156449
Sci Rep. 2018 Jul 11;8(1):10431
pubmed: 29993025
Mol Nutr Food Res. 2021 Oct;65(19):e2100346
pubmed: 34369649
Infect Immun. 1999 Jun;67(6):3031-9
pubmed: 10338516
J Nutr. 2002 Jul;132(7):1935-44
pubmed: 12097673
Carbohydr Polym. 2021 Jan 1;251:117093
pubmed: 33152851
Science. 2015 Aug 28;349(6251):989-93
pubmed: 26160380
J Nutr. 2015 Jan;145(1):159S-163S
pubmed: 25527674
Front Immunol. 2020 Oct 20;11:600973
pubmed: 33193456
Gut Pathog. 2016 Dec 22;8:67
pubmed: 28031748
PLoS Pathog. 2020 Mar 24;16(3):e1008448
pubmed: 32208465
Cell Microbiol. 2008 Mar;10(3):618-31
pubmed: 17979981
Nutrients. 2018 May 28;10(6):
pubmed: 29843428
Cell Host Microbe. 2007 Aug 16;2(2):119-29
pubmed: 18005726
Mucosal Immunol. 2014 Nov;7(6):1290-301
pubmed: 24646939
Front Microbiol. 2019 Feb 15;10:223
pubmed: 30828323
Am J Clin Nutr. 1978 Oct;31(10 Suppl):S43-52
pubmed: 707393
Front Immunol. 2018 Mar 01;9:383
pubmed: 29545800
Mol Nutr Food Res. 2016 Oct;60(10):2256-2266
pubmed: 27174558
Food Funct. 2021 Jan 21;12(2):881-891
pubmed: 33411865
J Nutr Biochem. 2017 Dec;50:38-45
pubmed: 29031241
Mol Nutr Food Res. 2017 Jan;61(1):
pubmed: 27198846
mSphere. 2017 Aug 23;2(4):
pubmed: 28861518
Am J Pathol. 2010 Sep;177(3):1320-32
pubmed: 20651246
Gut. 1981 Sep;22(9):763-79
pubmed: 7028579
Crit Rev Food Sci Nutr. 1997 Feb;37(1):47-73
pubmed: 9067088
Nat Microbiol. 2020 Feb;5(2):368-378
pubmed: 31873206
Lancet. 1972 Dec 30;2(7792):1408-12
pubmed: 4118696
Exp Mol Med. 2020 Sep;52(9):1364-1376
pubmed: 32908213
Science. 2012 Jun 8;336(6086):1325-9
pubmed: 22582016
J Microbiol Methods. 2016 Jul;126:76-7
pubmed: 27196638
Cell. 2016 Nov 17;167(5):1339-1353.e21
pubmed: 27863247
J Infect Dis. 2012 Jul 1;206(1):99-109
pubmed: 22430833
Front Immunol. 2019 Dec 19;10:2979
pubmed: 31921214
Cell Host Microbe. 2018 Jun 13;23(6):705-715
pubmed: 29902436