Cellular origins and lineage relationships of the intestinal epithelium.
differentiation
intestinal epithelium
intestinal stem cells
lineage hierarchy
single-cell RNA-sequencing
Journal
American journal of physiology. Gastrointestinal and liver physiology
ISSN: 1522-1547
Titre abrégé: Am J Physiol Gastrointest Liver Physiol
Pays: United States
ID NLM: 100901227
Informations de publication
Date de publication:
01 10 2021
01 10 2021
Historique:
pubmed:
26
8
2021
medline:
26
10
2021
entrez:
25
8
2021
Statut:
ppublish
Résumé
Knowledge of the development and hierarchical organization of tissues is key to understanding how they are perturbed in injury and disease, as well as how they may be therapeutically manipulated to restore homeostasis. The rapidly regenerating intestinal epithelium harbors diverse cell types and their lineage relationships have been studied using numerous approaches, from classical label-retaining and genetic lineage tracing methods to novel transcriptome-based annotations. Here, we describe the developmental trajectories that dictate differentiation and lineage specification in the intestinal epithelium. We focus on the most recent single-cell RNA-sequencing (scRNA-seq)-based strategies for understanding intestinal epithelial cell lineage relationships, underscoring how they have refined our view of the development of this tissue and highlighting their advantages and limitations. We emphasize how these technologies have been applied to understand the dynamics of intestinal epithelial cells in homeostatic and injury-induced regeneration models.
Identifiants
pubmed: 34431400
doi: 10.1152/ajpgi.00188.2021
pmc: PMC8560372
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
G413-G425Subventions
Organisme : NIDDK NIH HHS
ID : DP2 DK128801
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS103473
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32 DK083256
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007088
Pays : United States
Organisme : NIDDK NIH HHS
ID : U24 DK085532
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG067014
Pays : United States
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