Protective Effect of Nigella sativa and Nigella damascena Fixed Oils Against Aflatoxin Induced Mutagenicity in the Classical and Modified Ames Test.


Journal

Chemistry & biodiversity
ISSN: 1612-1880
Titre abrégé: Chem Biodivers
Pays: Switzerland
ID NLM: 101197449

Informations de publication

Date de publication:
Oct 2021
Historique:
received: 18 11 2020
accepted: 03 08 2021
pubmed: 26 8 2021
medline: 15 12 2021
entrez: 25 8 2021
Statut: ppublish

Résumé

The antioxidant and mutagenic/antimutagenic activities of the fixed oils from Nigella sativa (NSO) and Nigella damascena (NDO) seeds, obtained by cold press-extraction from the cultivar samples, were comparatively investigated for the first time. The antimutagenicity test was carried out using classical and modified Ames tests. The fatty acid composition of the fixed oils was characterized by gas chromatography-mass spectrometry (GC-MS) while the quantification of thymoquinone in the fixed oils was determined by UPC

Identifiants

pubmed: 34432933
doi: 10.1002/cbdv.202000936
doi:

Substances chimiques

Antimutagenic Agents 0
Antioxidants 0
Biphenyl Compounds 0
Picrates 0
Plant Oils 0
Protective Agents 0
Aflatoxin B1 9N2N2Y55MH
1,1-diphenyl-2-picrylhydrazyl DFD3H4VGDH

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2000936

Subventions

Organisme : Scientific and Technological Research Council of Turkey (TÜBİTAK)
ID : 117S866

Informations de copyright

© 2021 Wiley-VHCA AG, Zurich, Switzerland.

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Auteurs

Sinem Helvacıoğlu (S)

Department of Toxicology, Faculty of Pharmacy, Yeditepe University, 34755, Istanbul, Turkey.

Mohammad Charehsaz (M)

Department of Toxicology, Faculty of Pharmacy, Yeditepe University, 34755, Istanbul, Turkey.

Etil Güzelmeriç (E)

Department of Pharmacognosy, Faculty of Pharmacy, Yeditepe University, 34755, Istanbul, Turkey.

Mehmet Ali Oçkun (MA)

Faculty of Pharmacy, Yeditepe University, 34755, Istanbul, Turkey.

İrem Ayran (İ)

Selçuk University, Agriculture Faculty, Department of Medicinal Plants, 42130, Konya, Turkey.

Hasan Kırmızıbekmez (H)

Department of Pharmacognosy, Faculty of Pharmacy, Yeditepe University, 34755, Istanbul, Turkey.

Yüksel Kan (Y)

Selçuk University, Agriculture Faculty, Department of Medicinal Plants, 42130, Konya, Turkey.

Ahmet Aydın (A)

Department of Toxicology, Faculty of Pharmacy, Yeditepe University, 34755, Istanbul, Turkey.

Erdem Yeşilada (E)

Department of Pharmacognosy, Faculty of Pharmacy, Yeditepe University, 34755, Istanbul, Turkey.

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