Discovery of Amide-Functionalized Benzimidazolium Salts as Potent α-Glucosidase Inhibitors.
anti-diabetic studies
benzimidazole derivatives
benzimidazolium salts
molecular docking
α-glucosidase inhibition
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
06 Aug 2021
06 Aug 2021
Historique:
received:
30
06
2021
revised:
29
07
2021
accepted:
01
08
2021
entrez:
27
8
2021
pubmed:
28
8
2021
medline:
7
9
2021
Statut:
epublish
Résumé
α-Glucosidase inhibitors (AGIs) are used as medicines for the treatment of diabetes mellitus. The α-Glucosidase enzyme is present in the small intestine and is responsible for the breakdown of carbohydrates into sugars. The process results in an increase in blood sugar levels. AGIs slow down the digestion of carbohydrates that is helpful in controlling the sugar levels in the blood after meals. Among heterocyclic compounds, benzimidazole moiety is recognized as a potent bioactive scaffold for its wide range of biologically active derivatives. The aim of this study is to explore the α-glucosidase inhibition ability of benzimidazolium salts. In this study, two novel series of benzimidazolium salts, i.e., 1-benzyl-3-{2-(substituted) amino-2-oxoethyl}-1
Identifiants
pubmed: 34443347
pii: molecules26164760
doi: 10.3390/molecules26164760
pmc: PMC8400806
pii:
doi:
Substances chimiques
Amides
0
Benzimidazoles
0
Glycoside Hydrolase Inhibitors
0
Salts
0
benzimidazole
E24GX49LD8
alpha-Glucosidases
EC 3.2.1.20
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Higher Education Commission, Pakistan
ID : NRPU-5614
Organisme : Government College University, Faisalabad, Pakistan
Références
JAMA. 2003 Jul 23;290(4):486-94
pubmed: 12876091
Molecules. 2017 Oct 30;22(11):
pubmed: 29084182
Pak J Pharm Sci. 2015 Nov;28(6):2179-84
pubmed: 26639510
Bioorg Med Chem. 2017 Jan 1;25(1):421-439
pubmed: 27876249
Bioorg Med Chem. 2016 Nov 1;24(21):5103-5114
pubmed: 27576293
Bioorg Chem. 2020 Jan;94:103394
pubmed: 31699396
Molecules. 2019 Apr 04;24(7):
pubmed: 30987350
Bioorg Med Chem. 2016 Mar 15;24(6):1392-401
pubmed: 26879855
Bioorg Med Chem Lett. 2010 Aug 1;20(15):4420-3
pubmed: 20598536
Lancet. 2009 May 9;373(9675):1607-14
pubmed: 19395079
Molecules. 2020 Sep 18;25(18):
pubmed: 32962014
Bioorg Chem. 2017 Jun;72:21-31
pubmed: 28346872
Ann Pharmacother. 2000 Nov;34(11):1291-301
pubmed: 11098345
Eur J Med Chem. 2009 Oct;44(10):4028-33
pubmed: 19482384
Bioorg Chem. 2016 Oct;68:226-35
pubmed: 27572707
Eur J Med Chem. 2015 Mar 26;93:83-92
pubmed: 25659754
Molecules. 2017 Jan 30;22(2):
pubmed: 28146092
Sci Rep. 2021 Jun 7;11(1):11911
pubmed: 34099819
Bioorg Chem. 2018 Feb;76:468-477
pubmed: 29287256
Chemosphere. 2015 Jan;119 Suppl:S16-20
pubmed: 24745558
Molecules. 2021 May 20;26(10):
pubmed: 34065194
Prev Nutr Food Sci. 2020 Sep 30;25(3):263-271
pubmed: 33083375
Eur J Med Chem. 2017 Sep 8;137:211-220
pubmed: 28595066
Drugs. 2005;65(3):385-411
pubmed: 15669880
Pharmaceuticals (Basel). 2019 Oct 10;12(4):
pubmed: 31658729
Eur J Med Chem. 2017 May 5;131:92-106
pubmed: 28301816
Molecules. 2015 Aug 20;20(8):15206-23
pubmed: 26307956
Eur J Med Chem. 2019 Aug 15;176:343-377
pubmed: 31112894
Life Sci. 2013 Feb 27;92(3):187-92
pubmed: 23270944
Bioorg Chem. 2020 Aug;101:104002
pubmed: 32563964
Comput Biol Chem. 2020 Dec;89:107400
pubmed: 33068917
ACS Infect Dis. 2019 Mar 8;5(3):372-384
pubmed: 30608648
Bioorg Med Chem Lett. 2003 Jun 16;13(12):2017-20
pubmed: 12781186