Glycan Array Evaluation of Synthetic Epitopes between the Capsular Polysaccharides from
Antibodies
/ chemistry
Biosensing Techniques
Cross Reactions
Epitopes
/ chemistry
Glycoconjugates
/ analysis
Hexosamines
/ chemistry
Immobilized Proteins
/ chemistry
Polysaccharides, Bacterial
/ analysis
Serogroup
Serum
/ chemistry
Spectrometry, Fluorescence
Streptococcus pneumoniae
/ metabolism
Surface Properties
Journal
ACS chemical biology
ISSN: 1554-8937
Titre abrégé: ACS Chem Biol
Pays: United States
ID NLM: 101282906
Informations de publication
Date de publication:
17 09 2021
17 09 2021
Historique:
pubmed:
2
9
2021
medline:
24
11
2021
entrez:
1
9
2021
Statut:
ppublish
Résumé
Vaccination represents the most effective way to prevent invasive pneumococcal diseases. The glycoconjugate vaccines licensed so far are obtained from capsular polysaccharides (CPSs) of the most virulent serotypes. Protection is largely limited to the specific vaccine serotypes, and the continuous need for broader coverage to control the outbreak of emerging serotypes is pushing the development of new vaccine candidates. Indeed, the development of efficacious vaccine formulation is complicated by the high number of bacterial serotypes with different CPSs. In this context, to simplify vaccine composition, we propose the design of new saccharide fragments containing chemical structures shared by different serotypes as cross-reactive and potentially cross-protective common antigens. In particular, we focused on
Identifiants
pubmed: 34469105
doi: 10.1021/acschembio.1c00347
pmc: PMC8453487
doi:
Substances chimiques
Antibodies
0
Epitopes
0
Glycoconjugates
0
Hexosamines
0
Immobilized Proteins
0
Polysaccharides, Bacterial
0
N-acetylmannosamine
X80PR7P73R
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1671-1679Références
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