Synthesis of indole derivatives as diabetics II inhibitors and enzymatic kinetics study of α-glucosidase and α-amylase along with their in-silico study.

Catalytic Domain Computer Simulation Glycoside Hydrolase Inhibitors / chemistry Hydrogen Bonding Hypoglycemic Agents / chemistry Indoles / chemical synthesis Kinetics Molecular Docking Simulation Saccharomyces cerevisiae / enzymology Structure-Activity Relationship alpha-Amylases / antagonists & inhibitors alpha-Glucosidases / metabolism
Indole analogues Intestinal α-glucosidase enzymes interactions Kinetic study Pancreatic α-amylase

Journal

International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578

Informations de publication

Date de publication:
01 Nov 2021
Historique:
received: 28 06 2021
revised: 24 08 2021
accepted: 27 08 2021
pubmed: 6 9 2021
medline: 16 12 2021
entrez: 5 9 2021
Statut: ppublish

Résumé

In this study, we have investigated a series of indole-based compounds for their inhibitory study against pancreatic α-amylase and intestinal α-glucosidase activity. Inhibitors of carbohydrate degrading enzymes appear to have an essential role as antidiabetic drugs. All analogous exhibited good to moderate α-amylase (IC

Identifiants

DOI: 10.1016/j.ijbiomac.2021.08.207 PMID: 34481854
pubmed: 34481854
pii: S0141-8130(21)01884-5
doi: 10.1016/j.ijbiomac.2021.08.207
pii:
doi:

Substances chimiques

Glycoside Hydrolase Inhibitors 0
Hypoglycemic Agents 0
Indoles 0
alpha-Amylases EC 3.2.1.1
alpha-Glucosidases EC 3.2.1.20

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

301-318

Informations de copyright

Copyright © 2021 Elsevier B.V. All rights reserved.

Auteurs

Muhammad Taha (M)

Department of clinical pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia. Electronic address: mtaha@iau.edu.sa.

Ahlam Sayer Alrashedy (AS)

College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia.

Noor Barak Almandil (NB)

Department of clinical pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia.

Naveed Iqbal (N)

Department of Chemistry, University of Poonch, Rawalakot, AJK, Pakistan.

El Hassane Anouar (EH)

Department of Chemistry, College of Science and Humanities in Al-Kharj, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.

Muhammad Nawaz (M)

Department of Nano-Medicine Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia.

Nizam Uddin (N)

Department of Chemistry, University of Karachi, Karachi 75270, Pakistan.

Sridevi Chigurupati (S)

Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, Buraidah, 52571, Saudi Arabia.

Abdul Wadood (A)

Department of Biochemistry, Abdul Wali Khan University Mardan, Mardan 23200, Pakistan.

Fazal Rahim (F)

Department of Chemistry, Hazara University, Mansehra 21120, Pakistan.

Suprava Das (S)

Department of Pharmacology, Faculty of Medicine, AIMST University, Semeling, 08100 Bedong, Kedah, Malaysia.

Vijayan Venugopal (V)

School of Pharmacy, Sri Balaji Vidyapeeth (Deemed to be University), Puducherry 607402, India.

Faisal Nawaz (F)

Department of Chemistry, University of Wah, Quaid Avenue, Wah Cantt 47000, Pakistan.

Khalid Mohammed Khan (KM)

H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.

Articles similaires

Decoding the genomic terrain: functional insights into 14 chemosensory proteins in whitefly Bemisia tabaci Asia II-1.

M N Rudra Gouda, Sabtharishi Subramanian
1.00
Animals Hemiptera Insect Proteins Phylogeny Insecticides

A new estimator of between study variance of standardized mean difference in meta-analysis.

Ramlah H Albayyat, Hajar S Aljohani, Dalia K Alnagar
1.00
Humans Meta-Analysis as Topic Sample Size Models, Statistical Computer Simulation

An arithmetic operation P system based on symmetric ternary system.

Hai Nan, Jie Zhang, Ping Guo et al.
1.00
Humans Algorithms Software Artificial Intelligence Computer Simulation

Assessment of first-touch skills in robotic surgical training using hi-Sim and the hinotori surgical robot system among surgeons and novices.

Takeshi Urade, Nobuaki Yamasaki, Munenori Uemura et al.
1.00
Humans Robotic Surgical Procedures Clinical Competence Male Female

Classifications MeSH

questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Éléments structuraux des protéines › Domaine catalytique › Synthesis of indole derivatives as diabetics...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Synthesis of indole derivatives as diabetics...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hypoglycémiants › Inhibiteurs des glycoside hydrolases › Synthesis of indole derivatives as diabetics...
questionsmedicales.fr › Phénomènes chimiques › Liaison hydrogène › Synthesis of indole derivatives as diabetics...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hypoglycémiants › Synthesis of indole derivatives as diabetics...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Indoles › Synthesis of indole derivatives as diabetics...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Cinétique › Synthesis of indole derivatives as diabetics...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Synthesis of indole derivatives as diabetics...
questionsmedicales.fr › Eucaryotes › Champignons › Levures › Saccharomyces › Saccharomyces cerevisiae › Synthesis of indole derivatives as diabetics...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Synthesis of indole derivatives as diabetics...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Glycosidases › Amylases › alpha-Amylases › Synthesis of indole derivatives as diabetics...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Glycosidases › Glucosidases › alpha-Glucosidase › Synthesis of indole derivatives as diabetics...