Analysis of the proximal promoter of the human colon-specific B4GALNT2 (Sd
B4GALNT2
Colon
Core promoter
ETS1
Transcriptional regulation
Journal
Biochimica et biophysica acta. Gene regulatory mechanisms
ISSN: 1876-4320
Titre abrégé: Biochim Biophys Acta Gene Regul Mech
Pays: Netherlands
ID NLM: 101731723
Informations de publication
Date de publication:
Historique:
received:
16
06
2021
revised:
26
07
2021
accepted:
09
08
2021
pubmed:
10
9
2021
medline:
31
12
2021
entrez:
9
9
2021
Statut:
ppublish
Résumé
The Sd To clarify the molecular basis of Sd A short cis-regulatory region restricted to the -72 to +12 area upstream of the B4GALNT2 short-type transcript variant contained the essential promoter activity that drives the expression of the human B4GALNT2 regardless of the cell type. We further showed that B4GALNT2 transcriptional activation mostly requires ETS1 and to a lesser extent SP1. Results presented herein are expected to provide clues to better understand B4GALNT2 regulatory mechanisms.
Sections du résumé
BACKGROUND
The Sd
METHODS
To clarify the molecular basis of Sd
RESULTS
A short cis-regulatory region restricted to the -72 to +12 area upstream of the B4GALNT2 short-type transcript variant contained the essential promoter activity that drives the expression of the human B4GALNT2 regardless of the cell type. We further showed that B4GALNT2 transcriptional activation mostly requires ETS1 and to a lesser extent SP1.
CONCLUSIONS
Results presented herein are expected to provide clues to better understand B4GALNT2 regulatory mechanisms.
Identifiants
pubmed: 34500083
pii: S1874-9399(21)00065-1
doi: 10.1016/j.bbagrm.2021.194747
pii:
doi:
Substances chimiques
ETS1 protein, human
0
Oligosaccharides
0
Proto-Oncogene Protein c-ets-1
0
Sd(a) determinant
0
Sp1 Transcription Factor
0
SP1 protein, human
0
N-Acetylgalactosaminyltransferases
EC 2.4.1.-
beta-1,4-N-acetyl-galactosaminyl transferase 2
EC 2.4.1.165
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
194747Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.