Evolutionarily conserved transcriptional landscape of the heart defining the chamber specific physiology.
Cardiac transcriptome
Chamber specificity
lncRNA conservation
Journal
Genomics
ISSN: 1089-8646
Titre abrégé: Genomics
Pays: United States
ID NLM: 8800135
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
28
04
2021
revised:
17
08
2021
accepted:
05
09
2021
pubmed:
11
9
2021
medline:
1
4
2022
entrez:
10
9
2021
Statut:
ppublish
Résumé
Cardiovascular disease (CVD) remains the leading cause of death worldwide. A deeper characterization of regional transcription patterns within different heart chambers may aid to improve our understanding of the molecular mechanisms involved in myocardial function and further, our ability to develop novel therapeutic strategies. Here, we used RNA sequencing to determine differentially expressed protein coding (PC) and long non-coding (lncRNA) transcripts within the heart chambers across seven vertebrate species and identified evolutionarily conserved chamber specific genes, lncRNAs and pathways. We investigated lncRNA homologs based on sequence, secondary structure, synteny and expressional conservation and found most lncRNAs to be conserved by synteny. Regional co-expression patterns of transcripts are modulated by multiple factors, including genomic overlap, strandedness and transcript biotype. Finally, we provide a community resource designated EvoACTG, which informs researchers on the conserved yet intertwined nature of the coding and non-coding cardiac transcriptome across popular model organisms in CVD research.
Identifiants
pubmed: 34506887
pii: S0888-7543(21)00343-8
doi: 10.1016/j.ygeno.2021.09.002
pii:
doi:
Substances chimiques
RNA, Long Noncoding
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3782-3792Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.