Positron emission tomography imaging of serotonin degeneration and beta-amyloid deposition in late-life depression evaluated with multi-modal partial least squares.
Journal
Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664
Informations de publication
Date de publication:
13 09 2021
13 09 2021
Historique:
received:
13
04
2021
accepted:
26
07
2021
revised:
13
07
2021
entrez:
14
9
2021
pubmed:
15
9
2021
medline:
12
10
2021
Statut:
epublish
Résumé
Depression in late-life is associated with increased risk of cognitive decline and development of all-cause dementia. The neurobiology of late-life depression (LLD) may involve both neurochemical and neurodegenerative mechanisms that are common to depression and dementia. Transgenic amyloid mouse models show evidence of early degeneration of monoamine systems. Informed by these preclinical data, the hypotheses were tested that a spatial covariance pattern of higher beta-amyloid (Aβ) and lower serotonin transporter availability (5-HTT) in frontal, temporal, and parietal cortical regions would distinguish LLD patients from healthy controls and the expression of this pattern would be associated with greater depressive symptoms. Twenty un-medicated LLD patients who met DSM-V criteria for major depression and 20 healthy controls underwent PET imaging with radiotracers for Aβ ([
Identifiants
pubmed: 34518514
doi: 10.1038/s41398-021-01539-9
pii: 10.1038/s41398-021-01539-9
pmc: PMC8437937
doi:
Substances chimiques
Amyloid beta-Peptides
0
Aniline Compounds
0
Serotonin
333DO1RDJY
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
473Subventions
Organisme : NIMH NIH HHS
ID : R01 MH064823
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG066507
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001079
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG041633
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG059390
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG072980
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG038893
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG019610
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH086881
Pays : United States
Informations de copyright
© 2021. The Author(s).
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