Collaboration of a Detrimental HLA-B*35:01 Allele with HLA-A*24:02 in Coevolution of HIV-1 with T Cells Leading to Poorer Clinical Outcomes.
CD8
CTL
HIV-1
HLA
TCR
escape mutation
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
09 11 2021
09 11 2021
Historique:
pubmed:
16
9
2021
medline:
29
12
2021
entrez:
15
9
2021
Statut:
ppublish
Résumé
Although mutant-specific T cells are elicited in some individuals infected with HIV-1 mutant viruses, the detailed characteristics of these T cells remain unknown. A recent study showed that the accumulation of strains expressing Nef135F, which were selected by HLA-A*24:02-restricted T cells, was associated with poor outcomes in individuals with the detrimental HLA-B*35:01 allele and that HLA-B*35:01-restricted NefYF9 (Nef135-143)-specific T cells failed to recognize target cells infected with Nef135F mutant viruses. Here, we investigated HLA-B*35:01-restricted T cells specific for the NefFF9 epitope incorporating the Nef135F mutation. Longitudinal T-cell receptor (TCR) clonotype analysis demonstrated that 3 types of HLA-B*35:01-restricted T cells (wild-type [WT] specific, mutant specific, and cross-reactive) with different T cell repertoires were elicited during the clinical course. HLA-B*35:01
Identifiants
pubmed: 34523962
doi: 10.1128/JVI.01259-21
pmc: PMC8577379
doi:
Substances chimiques
Epitopes, T-Lymphocyte
0
HLA-A*24:02 antigen
0
HLA-A24 Antigen
0
HLA-B Antigens
0
HLA-B*35:01 antigen
0
HLA-B35 Antigen
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0125921Subventions
Organisme : Japan Agency for Medical Research and Development (AMED)
ID : 15fk0410019
Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : 20H03726
Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : 20K07549
Références
PLoS Pathog. 2019 Aug 9;15(8):e1007970
pubmed: 31398241
PLoS One. 2009 Aug 19;4(8):e6687
pubmed: 19690614
PLoS One. 2011 Apr 22;6(4):e19018
pubmed: 21544209
Trends Microbiol. 2015 Apr;23(4):212-24
pubmed: 25613992
J Exp Med. 2006 Oct 2;203(10):2281-92
pubmed: 16954372
Science. 1999 Mar 12;283(5408):1748-52
pubmed: 10073943
J Virol. 2012 Dec;86(23):12643-54
pubmed: 22973023
J Virol. 2018 Dec 10;93(1):
pubmed: 30333167
Nat Rev Immunol. 2004 Aug;4(8):630-40
pubmed: 15286729
J Virol. 1994 Jul;68(7):4650-5
pubmed: 8207839
Nat Med. 2016 Jun;22(6):606-13
pubmed: 27183217
Nature. 2009 Apr 2;458(7238):641-5
pubmed: 19242411
J Virol. 2017 Jan 31;91(4):
pubmed: 27903797
Nat Immunol. 2009 Jan;10(1):29-37
pubmed: 19043418
J Virol. 2005 Oct;79(20):12952-60
pubmed: 16188997
Science. 1996 Oct 4;274(5284):94-6
pubmed: 8810254
AIDS. 2021 Jan 1;35(1):33-43
pubmed: 33031103
PLoS Genet. 2014 Apr 24;10(4):e1004295
pubmed: 24762668
PLoS Pathog. 2020 Aug 6;16(8):e1008696
pubmed: 32760139
J Virol. 1994 Sep;68(9):6103-10
pubmed: 8057491
PLoS One. 2012;7(7):e40386
pubmed: 22792299
Cell Rep. 2016 Jun 7;15(10):2279-2291
pubmed: 27239036
PLoS Pathog. 2012;8(8):e1002840
pubmed: 22916009
Nat Med. 2004 Mar;10(3):282-9
pubmed: 14770175
PLoS Pathog. 2020 Dec 28;16(12):e1009177
pubmed: 33370400
Science. 2010 Dec 10;330(6010):1551-7
pubmed: 21051598
J Infect Dis. 2015 Nov 1;212(9):1376-86
pubmed: 25883386
Eur J Immunol. 2000 Sep;30(9):2521-30
pubmed: 11009085
J Virol. 2008 Jan;82(1):138-47
pubmed: 17959671
AIDS. 1990 Mar;4(3):177-84
pubmed: 1693514
Science. 2008 May 9;320(5877):760-4
pubmed: 18467582
J Virol. 2020 Sep 15;94(19):
pubmed: 32699092
Nature. 2006 Sep 21;443(7109):350-4
pubmed: 16921384
J Virol. 2012 Oct;86(19):10870-2
pubmed: 22811530
Science. 1998 Mar 27;279(5359):2103-6
pubmed: 9516110
Nat Med. 2006 Oct;12(10):1198-202
pubmed: 16917489
J Virol. 2002 Dec;76(24):12603-10
pubmed: 12438586
Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14733-8
pubmed: 20679213
EBioMedicine. 2018 Oct;36:103-112
pubmed: 30249546
AIDS. 2016 Mar 13;30(5):681-9
pubmed: 26595539
Front Immunol. 2020 Sep 11;11:2188
pubmed: 33072082
J Exp Med. 2009 Dec 21;206(13):2959-66
pubmed: 20008523
Int Immunol. 2002 May;14(5):445-51
pubmed: 11978774
PLoS Pathog. 2014 Sep 25;10(9):e1004380
pubmed: 25255144
J Virol. 2014 May;88(9):4764-75
pubmed: 24522911
N Engl J Med. 2001 May 31;344(22):1668-75
pubmed: 11386265
PLoS Pathog. 2016 Jul 14;12(7):e1005661
pubmed: 27415828
Eur J Immunol. 2006 Sep;36(9):2359-66
pubmed: 16917959
Science. 1986 Dec 19;234(4783):1563-6
pubmed: 2431484
J Virol. 2012 Feb;86(4):1971-81
pubmed: 22156528
Science. 2002 May 24;296(5572):1439-43
pubmed: 12029127