SREBP1-induced fatty acid synthesis depletes macrophages antioxidant defences to promote their alternative activation.

Animals Antioxidants / metabolism Dexamethasone / pharmacology Fatty Acids / biosynthesis Humans Interleukin-4 / pharmacology Lipopolysaccharides / pharmacology Macrophage Activation Macrophages / drug effects Mice Mice, Knockout Nippostrongylus / isolation & purification RAW 264.7 Cells Sequence Analysis, RNA / methods Sterol Regulatory Element Binding Protein 1 / metabolism Strongylida Infections / immunology Up-Regulation

Journal

Nature metabolism
ISSN: 2522-5812
Titre abrégé: Nat Metab
Pays: Germany
ID NLM: 101736592

Informations de publication

Date de publication:
09 2021
Historique:
received: 21 12 2019
accepted: 22 07 2021
pubmed: 18 9 2021
medline: 15 12 2021
entrez: 17 9 2021
Statut: ppublish

Résumé

Macrophages exhibit a spectrum of activation states ranging from classical to alternative activation

Identifiants

DOI: 10.1038/s42255-021-00440-5 PMID: 34531575 PMC: PMC7611716
pubmed: 34531575
doi: 10.1038/s42255-021-00440-5
pii: 10.1038/s42255-021-00440-5
pmc: PMC7611716
mid: EMS131962
doi:

Substances chimiques

Antioxidants 0
Fatty Acids 0
Lipopolysaccharides 0
SREBF1 protein, human 0
Sterol Regulatory Element Binding Protein 1 0
Interleukin-4 207137-56-2
Dexamethasone 7S5I7G3JQL

Types de publication

Letter Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1150-1162

Subventions

Organisme : Medical Research Council
ID : U105178805
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_U105178805
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RG/12/13/29853
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0802051
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 100574
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_G0802535
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12012/5
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RG/18/7/33636
Pays : United Kingdom
Organisme : Wellcome Trust (Wellcome)
ID : 106260/Z/14/Z
Organisme : Wellcome Trust
ID : 100963
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 106260
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00014/2
Pays : United Kingdom
Organisme : Wellcome Trust (Wellcome)
ID : 100574/Z/12/Z
Organisme : Medical Research Council
ID : MC_UU_12012/2
Pays : United Kingdom
Organisme : Wellcome Trust (Wellcome)
ID : 100963/Z/13/Z
Organisme : Medical Research Council
ID : G0400192
Pays : United Kingdom
Organisme : Medical Research Council
ID : MRC_MC_UU_12012/5
Pays : United Kingdom

Informations de copyright

© 2021. The Author(s), under exclusive licence to Springer Nature Limited.

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Auteurs

Guillaume Bidault (G)

University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, MDU MRC, Addenbrooke's Hospital, Cambridge, UK. gb483@medschl.cam.ac.uk.
ORCID: 0000-0002-8396-9962

Samuel Virtue (S)

University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, MDU MRC, Addenbrooke's Hospital, Cambridge, UK.
ORCID: 0000-0002-9545-5432

Kasparas Petkevicius (K)

University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, MDU MRC, Addenbrooke's Hospital, Cambridge, UK.
ORCID: 0000-0003-2295-6065

Helen E Jolin (HE)

Medical Research Council, Laboratory of Molecular Biology, Cambridge, UK.

Aurélien Dugourd (A)

Institute for Computational Biomedicine, Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, BioQuant, Heidelberg, Germany.
Faculty of Medicine, Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany.

Anne-Claire Guénantin (AC)

University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, MDU MRC, Addenbrooke's Hospital, Cambridge, UK.
Wellcome Trust Sanger Institute, Cambridge, UK.

Jennifer Leggat (J)

University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, MDU MRC, Addenbrooke's Hospital, Cambridge, UK.
ORCID: 0000-0002-1040-6827

Betania Mahler-Araujo (B)

University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, MDU MRC, Addenbrooke's Hospital, Cambridge, UK.

Brian Y H Lam (BYH)

University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, MDU MRC, Addenbrooke's Hospital, Cambridge, UK.

Marcella K Ma (MK)

University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, MDU MRC, Addenbrooke's Hospital, Cambridge, UK.
ORCID: 0000-0002-2228-7466

Martin Dale (M)

University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, MDU MRC, Addenbrooke's Hospital, Cambridge, UK.

Stefania Carobbio (S)

University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, MDU MRC, Addenbrooke's Hospital, Cambridge, UK.
Wellcome Trust Sanger Institute, Cambridge, UK.

Arthur Kaser (A)

Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), and Division of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Cambridge, UK.

Padraic G Fallon (PG)

School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.

Julio Saez-Rodriguez (J)

Institute for Computational Biomedicine, Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, BioQuant, Heidelberg, Germany.
ORCID: 0000-0002-8552-8976

Andrew N J McKenzie (ANJ)

Medical Research Council, Laboratory of Molecular Biology, Cambridge, UK.
ORCID: 0000-0001-9757-2512

Antonio Vidal-Puig (A)

University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, MDU MRC, Addenbrooke's Hospital, Cambridge, UK. ajv22@medschl.cam.ac.uk.
Wellcome Trust Sanger Institute, Cambridge, UK. ajv22@medschl.cam.ac.uk.
ORCID: 0000-0003-4220-9577

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › SREBP1-induced fatty acid synthesis depletes...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Antioxydants › SREBP1-induced fatty acid synthesis depletes...
questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Stéroïdes fluorés › Dexaméthasone › SREBP1-induced fatty acid synthesis depletes...
questionsmedicales.fr › Lipides › Acides gras › SREBP1-induced fatty acid synthesis depletes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › SREBP1-induced fatty acid synthesis depletes...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-4 › SREBP1-induced fatty acid synthesis depletes...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Toxines bactériennes › Endotoxines › Lipopolysaccharides › SREBP1-induced fatty acid synthesis depletes...
questionsmedicales.fr › Phénomènes du système immunitaire › Cytotoxicité immunologique › Activation des macrophages › SREBP1-induced fatty acid synthesis depletes...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › SREBP1-induced fatty acid synthesis depletes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › SREBP1-induced fatty acid synthesis depletes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › SREBP1-induced fatty acid synthesis depletes...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Helminthes › Nematoda › Chromadorea › Strongylida › Heligmosomatoidea › Nippostrongylus › SREBP1-induced fatty acid synthesis depletes...
questionsmedicales.fr › Cellules › Cellules RAW 264.7 › SREBP1-induced fatty acid synthesis depletes...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ARN › SREBP1-induced fatty acid synthesis depletes...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique et à glissière à leucines › Facteurs de transcription à motifs basiques hélice-boucle-hélice et à glissière à leucines › Protéines de liaison à l'élément de régulation des stérols › Protéine-1 de liaison à l'élément de régulation des stérols › SREBP1-induced fatty acid synthesis depletes...
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