Genome-Wide Association Study of NAFLD Using Electronic Health Records.
Acyltransferases
/ genetics
Adaptor Proteins, Signal Transducing
/ genetics
Apolipoproteins E
/ genetics
Case-Control Studies
Codon, Nonsense
Electronic Health Records
Female
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Intracellular Signaling Peptides and Proteins
/ genetics
Male
Membrane Proteins
/ genetics
Middle Aged
Mutation, Missense
Non-alcoholic Fatty Liver Disease
/ genetics
Peptide Fragments
/ genetics
Phospholipases A2, Calcium-Independent
/ genetics
Protein Serine-Threonine Kinases
/ antagonists & inhibitors
Journal
Hepatology communications
ISSN: 2471-254X
Titre abrégé: Hepatol Commun
Pays: United States
ID NLM: 101695860
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
received:
02
06
2021
accepted:
04
07
2021
pubmed:
19
9
2021
medline:
8
3
2022
entrez:
18
9
2021
Statut:
ppublish
Résumé
Genome-wide association studies (GWAS) have identified several risk loci for nonalcoholic fatty liver disease (NAFLD). Previous studies have largely relied on small sample sizes and have assessed quantitative traits. We performed a case-control GWAS in the UK Biobank using recorded diagnosis of NAFLD based on diagnostic codes recommended in recent consensus guidelines. We performed a GWAS of 4,761 cases of NAFLD and 373,227 healthy controls without evidence of NAFLD. Sensitivity analyses were performed excluding other co-existing hepatic pathology, adjusting for body mass index (BMI) and adjusting for alcohol intake. A total of 9,723,654 variants were assessed by logistic regression adjusted for age, sex, genetic principal components, and genotyping batch. We performed a GWAS meta-analysis using available summary association statistics. Six risk loci were identified (P < 5*10
Identifiants
pubmed: 34535985
doi: 10.1002/hep4.1805
pmc: PMC8793997
doi:
Substances chimiques
Adaptor Proteins, Signal Transducing
0
Apolipoproteins E
0
Codon, Nonsense
0
GCKR protein, human
0
Intracellular Signaling Peptides and Proteins
0
Membrane Proteins
0
Peptide Fragments
0
TM6SF2 protein, human
0
TRIB1 protein, human
0
apolipoprotein E (133-149)
0
Acyltransferases
EC 2.3.-
MARK1 protein, human
EC 2.7.1.-
Protein Serine-Threonine Kinases
EC 2.7.11.1
adiponutrin, human
EC 3.1.1.3
Phospholipases A2, Calcium-Independent
EC 3.1.1.4
Types de publication
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
297-308Subventions
Organisme : Chief Scientist Office
ID : CZD/16/6
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 216767/Z/19/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 204979/Z/16/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 210752/Z/18/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/W015919/1
Pays : United Kingdom
Organisme : British Heart Foundation
ID : CH/F/21/90010
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RE/18/5/34216
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 104036/Z/14/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00007/10
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/T008008/1
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/16/14/32023
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N008340/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 219542/Z/19/Z
Pays : United Kingdom
Informations de copyright
© 2021 The Authors. Hepatology Communications published by Wiley Periodicals LLC on behalf of the American Association for the Study of Liver Diseases.
Références
BMJ Open Gastroenterol. 2015 Feb 17;2(1):e000019
pubmed: 26462272
PLoS Genet. 2011 Mar;7(3):e1001324
pubmed: 21423719
Clin Mol Hepatol. 2017 Mar;23(1):1-12
pubmed: 28268262
Hum Genet. 2013 Jul;132(7):783-92
pubmed: 23535911
N Engl J Med. 2018 Mar 22;378(12):1096-1106
pubmed: 29562163
PLoS Med. 2009 Feb 3;6(2):e22
pubmed: 19192942
J Gastroenterol. 2007 Jul;42(7):573-82
pubmed: 17653654
Dig Dis Sci. 2007 Dec;52(12):3399-403
pubmed: 17431774
Hepatology. 2007 Apr;45(4):846-54
pubmed: 17393509
Hepatol Commun. 2020 Jun 25;4(8):1112-1123
pubmed: 32766472
Gastroenterology. 2010 Nov;139(5):1567-76, 1576.e1-6
pubmed: 20708005
Liver Int. 2013 Oct;33(9):1398-405
pubmed: 23763360
Nat Commun. 2014 Jun 30;5:4309
pubmed: 24978903
J Hepatol. 2020 Sep;73(3):505-515
pubmed: 32298765
Gastroenterology. 2021 Apr;160(5):1620-1633.e13
pubmed: 33310085
Nat Rev Gastroenterol Hepatol. 2018 Jan;15(1):11-20
pubmed: 28930295
Nat Genet. 2015 Mar;47(3):291-5
pubmed: 25642630
Hepatology. 2007 Jul;46(1):32-6
pubmed: 17567829
Eur J Hum Genet. 2011 Jul;19(7):807-12
pubmed: 21407268
Hepatology. 2021 Jul;74(1):474-482
pubmed: 33486773
J Pediatr. 2017 Nov;190:100-107.e2
pubmed: 28918882
Nat Genet. 2017 Jun;49(6):842-847
pubmed: 28436986
J Hepatol. 2021 Jan;74(1):20-30
pubmed: 32882372
Mol Biol Rep. 2012 Jul;39(7):7381-8
pubmed: 22350157
J Hepatol. 2020 Aug;73(2):241-251
pubmed: 32247823
J Biol Chem. 2001 Jun 8;276(23):19778-86
pubmed: 11279066
JAMA. 2007 Sep 19;298(11):1300-11
pubmed: 17878422
J Physiol Pharmacol. 2013 Dec;64(6):711-7
pubmed: 24388885
PLoS Genet. 2020 Apr 13;16(4):e1008629
pubmed: 32282858
Nat Commun. 2017 Nov 28;8(1):1826
pubmed: 29184056
Bioinformatics. 2010 Sep 1;26(17):2190-1
pubmed: 20616382
Sci Rep. 2015 Aug 11;5:12931
pubmed: 26263022
Nat Genet. 2014 Apr;46(4):352-6
pubmed: 24531328
Hepatol Commun. 2020 May 19;4(8):1124-1135
pubmed: 32766473
BMC Med. 2019 Jul 17;17(1):135
pubmed: 31311600
Am J Epidemiol. 2017 Nov 1;186(9):1026-1034
pubmed: 28641372
Nat Rev Genet. 2010 Jul;11(7):499-511
pubmed: 20517342
PLoS One. 2019 Aug 6;14(8):e0220659
pubmed: 31386691
Nat Genet. 2008 Dec;40(12):1461-5
pubmed: 18820647
Gastroenterology. 2021 Apr;160(5):1634-1646.e7
pubmed: 33347879
Gut Liver. 2018 May 15;12(3):316-323
pubmed: 29271184
Hepatogastroenterology. 2005 Nov-Dec;52(66):1832-5
pubmed: 16334787
Dig Dis Sci. 2008 Dec;53(12):3218-24
pubmed: 18465245
PLoS One. 2012;7(6):e38322
pubmed: 22719876
J Lipid Res. 1998 Sep;39(9):1752-8
pubmed: 9741687
Hum Mol Genet. 2021 Jul 9;30(15):1443-1456
pubmed: 33856023
Hepatology. 2013 Feb;57(2):590-600
pubmed: 23213074
Bioinformatics. 2010 Nov 15;26(22):2867-73
pubmed: 20926424
Nucleic Acids Res. 2012 May;40(9):3777-84
pubmed: 22241776
Gut. 2020 Oct;69(10):1877-1884
pubmed: 32381514
Taehan Kan Hakhoe Chi. 2002 Dec;8(4):355-62
pubmed: 12506239