PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis.
Adult
Aged
Aged, 80 and over
Animals
Autophagy
CD8-Positive T-Lymphocytes
/ metabolism
Carcinogenesis
Cell Transformation, Neoplastic
Colorectal Neoplasms
/ metabolism
Cycloheximide
/ chemistry
Female
HEK293 Cells
Humans
Immunophenotyping
Interferon Regulatory Factor-3
/ metabolism
Interferons
/ metabolism
Isoenzymes
/ metabolism
Male
Membrane Proteins
/ metabolism
Mice
Middle Aged
Neoplasm Transplantation
Phosphorylation
Prognosis
Protein Kinase C
/ metabolism
Protein Serine-Threonine Kinases
/ genetics
Signal Transduction
Transcription Factors
Up-Regulation
STING
ULK1/2
atypical PKC
autophagy
chaperone-mediated autophagy
colorectal cancer
immunosuppression
immunosurveillance
immunotherapy
interferon
Journal
Molecular cell
ISSN: 1097-4164
Titre abrégé: Mol Cell
Pays: United States
ID NLM: 9802571
Informations de publication
Date de publication:
04 11 2021
04 11 2021
Historique:
received:
23
03
2021
revised:
19
07
2021
accepted:
27
08
2021
pubmed:
25
9
2021
medline:
8
1
2022
entrez:
24
9
2021
Statut:
ppublish
Résumé
The interferon (IFN) pathway is critical for cytotoxic T cell activation, which is central to tumor immunosurveillance and successful immunotherapy. We demonstrate here that PKCλ/ι inactivation results in the hyper-stimulation of the IFN cascade and the enhanced recruitment of CD8
Identifiants
pubmed: 34560002
pii: S1097-2765(21)00729-2
doi: 10.1016/j.molcel.2021.08.039
pmc: PMC8571054
mid: NIHMS1738530
pii:
doi:
Substances chimiques
IRF3 protein, human
0
Interferon Regulatory Factor-3
0
Isoenzymes
0
Membrane Proteins
0
STING1 protein, human
0
Transcription Factors
0
Interferons
9008-11-1
Cycloheximide
98600C0908
Ulk2 protein, mouse
EC 2.7.1.11
Protein Serine-Threonine Kinases
EC 2.7.11.1
TBK1 protein, human
EC 2.7.11.1
Ulk2 protein, human
EC 2.7.11.1
Protein Kinase C
EC 2.7.11.13
protein kinase C lambda
EC 2.7.11.13
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4509-4526.e10Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK124308
Pays : United States
Organisme : NIA NIH HHS
ID : R37 AG021904
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA211024
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK098408
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA207177
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA250025
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA218254
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
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