SMAD4 Feedback Activates the Canonical TGF-β Family Signaling Pathways.
Activin Receptors, Type I
/ genetics
Animals
Apoptosis
/ genetics
Blotting, Western
Bone Morphogenetic Protein Receptors, Type II
/ genetics
Chromatin Immunoprecipitation
Computational Biology
Epigenesis, Genetic
/ genetics
Female
Humans
Immunoprecipitation
Ovary
/ metabolism
Promoter Regions, Genetic
/ genetics
Real-Time Polymerase Chain Reaction
Receptor, Transforming Growth Factor-beta Type II
/ genetics
Signal Transduction
/ genetics
Smad4 Protein
/ genetics
Transforming Growth Factor beta
/ genetics
RNA sequencing
SMAD4
TGF-β family signaling pathways
feedback regulation
granulosa cells
pig
transcriptome
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
16 Sep 2021
16 Sep 2021
Historique:
received:
25
07
2021
revised:
06
09
2021
accepted:
14
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
3
11
2021
Statut:
epublish
Résumé
TGF-β family signaling pathways, including TGF-β and BMP pathways, are widely involved in the regulation of health and diseases through downstream SMADs, which are also regulated by multiple validated mechanisms, such as genetic regulation, epigenetic regulation, and feedback regulation. However, it is still unclear whether R-SMADs or Co-SMAD can feedback regulate the TGF-β family signaling pathways in granulosa cells (GCs). In this study, we report a novel mechanism underlying the feedback regulation of TGF-β family signaling pathways, i.e., SMAD4, the only Co-SMAD, positive feedback activates the TGF-β family signaling pathways in GCs with a basal level of TGF-β ligands by interacting with the core promoters of its upstream receptors. Mechanistically, SMAD4 acts as a transcription factor, and feedback activates the transcription of its upstream receptors, including
Identifiants
pubmed: 34576190
pii: ijms221810024
doi: 10.3390/ijms221810024
pmc: PMC8471547
pii:
doi:
Substances chimiques
Smad4 Protein
0
Transforming Growth Factor beta
0
ACVR1B protein, human
EC 2.7.11.30
Activin Receptors, Type I
EC 2.7.11.30
BMPR2 protein, human
EC 2.7.11.30
Bone Morphogenetic Protein Receptors, Type II
EC 2.7.11.30
Receptor, Transforming Growth Factor-beta Type II
EC 2.7.11.30
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Natural Science Foundation of China
ID : 31772568
Organisme : National Natural Science Foundation of China
ID : 31902130
Organisme : Qinglan Project of Jiangsu Province of China
ID : 2020
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