Detailed characterization of the transcriptome of single B cells in mantle cell lymphoma suggesting a potential use for SOX4.

Aged Aged, 80 and over B-Lymphocytes / metabolism Bone Marrow / pathology Cell Differentiation / genetics Female Gene Expression Regulation, Neoplastic Humans Lymphoma, Mantle-Cell / genetics Male Middle Aged RNA-Seq SOXC Transcription Factors / metabolism Single-Cell Analysis

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
27 09 2021
Historique:
received: 07 06 2021
accepted: 07 09 2021
entrez: 28 9 2021
pubmed: 29 9 2021
medline: 28 12 2021
Statut: epublish

Résumé

Mantle cell lymphoma (MCL) is a malignancy arising from naive B lymphocytes with common bone marrow (BM) involvement. Although t(11;14) is a primary event in MCL development, the highly diverse molecular etiology and causal genomic events are still being explored. We investigated the transcriptome of CD19

Identifiants

DOI: 10.1038/s41598-021-98560-1 PMID: 34580376 PMC: PMC8476518
pubmed: 34580376
doi: 10.1038/s41598-021-98560-1
pii: 10.1038/s41598-021-98560-1
pmc: PMC8476518
doi:

Substances chimiques

SOX4 protein, human 0
SOXC Transcription Factors 0

Banques de données

figshare
['10.6084/m9.figshare.14743233']

Types de publication

Journal Article Observational Study

Langues

eng

Sous-ensembles de citation

IM

Pagination

19092

Informations de copyright

© 2021. The Author(s).

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Auteurs

Simone Valentin Hansen (S)

Hematology-Pathology Research Laboratory, Research Unit for Hematology and Research Unit for Pathology, University of Southern Denmark and Odense University Hospital, Odense, Denmark. simone.valentin.hansen@rsyd.dk.

Marcus Høy Hansen (M)

Hematology-Pathology Research Laboratory, Research Unit for Hematology and Research Unit for Pathology, University of Southern Denmark and Odense University Hospital, Odense, Denmark.

Oriane Cédile (O)

Hematology-Pathology Research Laboratory, Research Unit for Hematology and Research Unit for Pathology, University of Southern Denmark and Odense University Hospital, Odense, Denmark.
OPEN, Odense Patient Data Explorative Network, Odense University Hospital, Odense, Denmark.

Michael Boe Møller (MB)

Hematology-Pathology Research Laboratory, Research Unit for Hematology and Research Unit for Pathology, University of Southern Denmark and Odense University Hospital, Odense, Denmark.

Jacob Haaber (J)

Hematology-Pathology Research Laboratory, Research Unit for Hematology and Research Unit for Pathology, University of Southern Denmark and Odense University Hospital, Odense, Denmark.

Niels Abildgaard (N)

Hematology-Pathology Research Laboratory, Research Unit for Hematology and Research Unit for Pathology, University of Southern Denmark and Odense University Hospital, Odense, Denmark.
CITCO, Centre for Cellular Immune Therapy of Hematological Cancer Odense, Odense University Hospital, Odense, Denmark.

Charlotte Guldborg Nyvold (C)

Hematology-Pathology Research Laboratory, Research Unit for Hematology and Research Unit for Pathology, University of Southern Denmark and Odense University Hospital, Odense, Denmark.
OPEN, Odense Patient Data Explorative Network, Odense University Hospital, Odense, Denmark.
CITCO, Centre for Cellular Immune Therapy of Hematological Cancer Odense, Odense University Hospital, Odense, Denmark.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Detailed characterization of the transcriptome...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › Detailed characterization of the transcriptome...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes B › Detailed characterization of the transcriptome...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Moelle osseuse › Detailed characterization of the transcriptome...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Detailed characterization of the transcriptome...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › Detailed characterization of the transcriptome...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Detailed characterization of the transcriptome...
questionsmedicales.fr › Maladies du système immunitaire › Syndromes immunoprolifératifs › Syndromes lymphoprolifératifs › Lymphomes › Lymphome malin non hodgkinien › Lymphome à cellules du manteau › Detailed characterization of the transcriptome...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Detailed characterization of the transcriptome...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ARN › RNA-Seq › Detailed characterization of the transcriptome...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription SOX › Facteurs de transcription SOX-C › Detailed characterization of the transcriptome...
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Analyse sur cellule unique › Detailed characterization of the transcriptome...