Recurrent rewiring of the adult hippocampal mossy fiber system by a single transcriptional regulator, Id2.
Id2
adult brain rewiring
circuit formation
mossy fiber
single-cell RNA-seq
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
05 10 2021
05 10 2021
Historique:
accepted:
05
08
2021
entrez:
2
10
2021
pubmed:
3
10
2021
medline:
15
12
2021
Statut:
ppublish
Résumé
Circuit formation in the central nervous system has been historically studied during development, after which cell-autonomous and nonautonomous wiring factors inactivate. In principle, balanced reactivation of such factors could enable further wiring in adults, but their relative contributions may be circuit dependent and are largely unknown. Here, we investigated hippocampal mossy fiber sprouting to gain insight into wiring mechanisms in mature circuits. We found that sole ectopic expression of Id2 in granule cells is capable of driving mossy fiber sprouting in healthy adult mouse and rat. Mice with the new mossy fiber circuit solved spatial problems equally well as controls but appeared to rely on local rather than global spatial cues. Our results demonstrate reprogrammed connectivity in mature neurons by one defined factor and an assembly of a new synaptic circuit in adult brain.
Identifiants
pubmed: 34599103
pii: 2108239118
doi: 10.1073/pnas.2108239118
pmc: PMC8501755
pii:
doi:
Substances chimiques
Idb2 protein, mouse
0
Inhibitor of Differentiation Protein 2
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2021 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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