High-plex expression profiling reveals that implants drive spatiotemporal protein production and innate immune activation for tissue repair.
Journal
Acta biomaterialia
ISSN: 1878-7568
Titre abrégé: Acta Biomater
Pays: England
ID NLM: 101233144
Informations de publication
Date de publication:
15 01 2022
15 01 2022
Historique:
received:
08
06
2021
revised:
08
10
2021
accepted:
12
10
2021
pubmed:
22
10
2021
medline:
28
1
2022
entrez:
21
10
2021
Statut:
ppublish
Résumé
Surprisingly little clarity exists concerning effects of biomaterial properties on spatially localized protein expression, which drives implant success. Wound healing and tissue regeneration must be optimally supported by the implant, adsorbed proteins, immune cells, and fibroblasts; cells determine repair and functional recovery through protein production and regulation. However, not yet fully understood is how implants differentially drive spatial quantities of individual proteins both within the implant interior and the tissue surrounding it. Here we apply GeoMx
Identifiants
pubmed: 34673228
pii: S1742-7061(21)00685-1
doi: 10.1016/j.actbio.2021.10.018
pii:
doi:
Substances chimiques
Biocompatible Materials
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
342-350Subventions
Organisme : NICHD NIH HHS
ID : R21 HD087828
Pays : United States
Organisme : NIBIB NIH HHS
ID : T32 EB021966
Pays : United States
Informations de copyright
Copyright © 2021 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest PD, JR, and JG are employees and stockholders of NanoString Technologies, Inc.