Specific age-correlated activation of top hierarchical motor control areas during gait-like plantar stimulation: An fMRI study.
Adult
Aged
Aging
Brain
Brain Mapping
Female
Forefoot, Human
/ physiology
Gait
/ physiology
Globus Pallidus
/ diagnostic imaging
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Motor Cortex
/ diagnostic imaging
Physical Stimulation
Prefrontal Cortex
/ diagnostic imaging
Putamen
/ diagnostic imaging
Thalamus
/ diagnostic imaging
Visual Cortex
/ diagnostic imaging
Young Adult
aging
brain
functional magnetic resonance imaging
functional neuroimaging
gait
motor cortex
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
01 02 2022
01 02 2022
Historique:
revised:
09
10
2021
received:
18
04
2021
accepted:
11
10
2021
pubmed:
6
11
2021
medline:
29
3
2022
entrez:
5
11
2021
Statut:
ppublish
Résumé
A better understanding of gait disorders that are associated with aging is crucial to prevent adverse outcomes. The functional study of gait remains a thorny issue due to technical constraints inherent to neuroimaging procedures, as most of them require to stay supine and motionless. Using an MRI-compatible system of boots reproducing gait-like plantar stimulation, we investigated the correlation between age and brain fMRI activation during simulated gait in healthy adults. Sixty-seven right-handed healthy volunteers aged between 20 and 77 years old (49.2 ± 18.0 years; 35 women) were recruited. Two paradigms were assessed consecutively: (a) gait-like plantar stimulation and (b) chaotic and not gait-related plantar stimulation. Resulting statistical parametric maps were analyzed with a multiple-factor regression that included age and a threshold determined by Monte-Carlo simulation to fulfill a family-wise error rate correction of p < .05. In the first paradigm, there was an age-correlated activation of the right pallidum, thalamus and putamen. The second paradigm showed an age-correlated deactivation of both primary visual areas (V1). The subtraction between results of the first and second paradigms showed age-correlated activation of the right presupplementary motor area (Brodmann Area [BA] 6) and right mid-dorsolateral prefrontal cortex (BA9-10). Our results show age-correlated activity in areas that have been associated with the control of gait, highlighting the relevance of this simulation model for functional gait study. The specific progressive activation of top hierarchical control areas in simulated gait and advancing age corroborate a progressive loss of automation in healthy older adults.
Identifiants
pubmed: 34738281
doi: 10.1002/hbm.25691
pmc: PMC8720193
doi:
Banques de données
EudraCT
['2014—A01593-44']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
833-843Informations de copyright
© 2021 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
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