A giant NLR gene confers broad-spectrum resistance to Phytophthora sojae in soybean.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
05 11 2021
05 11 2021
Historique:
received:
01
07
2021
accepted:
06
10
2021
entrez:
6
11
2021
pubmed:
7
11
2021
medline:
24
12
2021
Statut:
epublish
Résumé
Phytophthora root and stem rot caused by P. sojae is a destructive soybean soil-borne disease found worldwide. Discovery of genes conferring broad-spectrum resistance to the pathogen is a need to prevent the outbreak of the disease. Here, we show that soybean Rps11 is a 27.7-kb nucleotide-binding site-leucine-rich repeat (NBS-LRR or NLR) gene conferring broad-spectrum resistance to the pathogen. Rps11 is located in a genomic region harboring a cluster of large NLR genes of a single origin in soybean, and is derived from rounds of unequal recombination. Such events result in promoter fusion and LRR expansion that may contribute to the broad resistance spectrum. The NLR gene cluster exhibits drastic structural diversification among phylogenetically representative varieties, including gene copy number variation ranging from five to 23 copies, and absence of allelic copies of Rps11 in any of the non-Rps11-donor varieties examined, exemplifying innovative evolution of NLR genes and NLR gene clusters.
Identifiants
pubmed: 34741017
doi: 10.1038/s41467-021-26554-8
pii: 10.1038/s41467-021-26554-8
pmc: PMC8571336
doi:
Substances chimiques
NLR Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6263Informations de copyright
© 2021. The Author(s).
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