Multi-material 3D printing of programmable and stretchable oromucosal patches for delivery of saquinavir.
3D printing
Buccal delivery
Direct ink writing
Microenvironmental pH
Oromucosal patch
Saquinavir
Journal
International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127
Informations de publication
Date de publication:
15 Dec 2021
15 Dec 2021
Historique:
received:
21
09
2021
revised:
19
10
2021
accepted:
23
10
2021
pubmed:
9
11
2021
medline:
15
12
2021
entrez:
8
11
2021
Statut:
ppublish
Résumé
Oromucosal patches for drug delivery allow fast onset of action and ability to circumvent hepatic first pass metabolism of drugs. While conventional fabrication methods such as solvent casting or hot melt extrusion are ideal for scalable production of low-cost delivery patches, these methods chiefly allow for simple, homogenous patch designs. As alternative, a multi-material direct-ink-write 3D printing for rapid fabrication of complex oromucosal patches with unique design features was demonstrated in the present study. Specifically, three print-materials: an acidic saquinavir-loaded hydroxypropyl methylcellulose ink, an alkaline effervescent sodium carbonate-loaded ink, and a methyl cellulose backing material were combined in various designs. The CO
Identifiants
pubmed: 34748810
pii: S0378-5173(21)01042-5
doi: 10.1016/j.ijpharm.2021.121236
pii:
doi:
Substances chimiques
Hypromellose Derivatives
3NXW29V3WO
Saquinavir
L3JE09KZ2F
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
121236Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.