Targeting Oxidative Stress: Novel Coumarin-Based Inverse Agonists of GPR55.
8-Iso-PGF2α
GPR55
ROS
coumarin-based compounds
inverse agonism
oxidative stress
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
28 Oct 2021
28 Oct 2021
Historique:
received:
21
09
2021
revised:
14
10
2021
accepted:
24
10
2021
entrez:
13
11
2021
pubmed:
14
11
2021
medline:
24
12
2021
Statut:
epublish
Résumé
Oxidative stress is associated with different neurological and psychiatric diseases. Therefore, development of new pharmaceuticals targeting oxidative dysregulation might be a promising approach to treat these diseases. The G-protein coupled receptor 55 (GPR55) is broadly expressed in central nervous tissues and cells and is involved in the regulation of inflammatory and oxidative cell homeostasis. We have recently shown that coumarin-based compounds enfold inverse agonistic activities at GPR55 resulting in the inhibition of prostaglandin E
Identifiants
pubmed: 34769094
pii: ijms222111665
doi: 10.3390/ijms222111665
pmc: PMC8584154
pii:
doi:
Substances chimiques
Coumarins
0
GPR55 protein, human
0
GPR55 protein, mouse
0
Receptors, Cannabinoid
0
coumarin
A4VZ22K1WT
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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