Acute Ischemia of Lower Extremities Caused by Ergotamine Toxicity due to Pharmacologic Interaction With Cobicistat in an HIV-Positive Patient.
Adrenergic alpha-1 Receptor Agonists
/ adverse effects
Anti-HIV Agents
/ adverse effects
Cobicistat
/ adverse effects
Drug Interactions
Ergotamine
/ adverse effects
Ergotism
/ diagnosis
HIV Infections
/ complications
Humans
Ischemia
/ chemically induced
Lower Extremity
/ blood supply
Male
Migraine Disorders
/ drug therapy
Young Adult
Journal
Annals of vascular surgery
ISSN: 1615-5947
Titre abrégé: Ann Vasc Surg
Pays: Netherlands
ID NLM: 8703941
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
15
05
2021
revised:
19
08
2021
accepted:
02
09
2021
pubmed:
15
11
2021
medline:
23
3
2022
entrez:
14
11
2021
Statut:
ppublish
Résumé
Ergotism is an uncommon condition that affects patients with exposure to ergot alkaloids causing ischemia of extremities. We report the case of lower extremities ischemia caused by ergot toxicity in a human immunodeficiency virus (HIV) positive individual due to the interaction between ergot alkaloid and Cobicistat. In addition, we present a brief review of medical, and pharmacological aspects of this condition. To our knowledge, this is the second reported case describing this interaction.
Identifiants
pubmed: 34775015
pii: S0890-5096(21)00798-6
doi: 10.1016/j.avsg.2021.09.023
pii:
doi:
Substances chimiques
Adrenergic alpha-1 Receptor Agonists
0
Anti-HIV Agents
0
Cobicistat
LW2E03M5PG
Ergotamine
PR834Q503T
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
392.e1-392.e6Informations de copyright
Copyright © 2021. Published by Elsevier Inc.