Integrative Omics Analysis Unravels Microvascular Inflammation-Related Pathways in Kidney Allograft Biopsies.
Biopsy
Europe
Gene Expression Profiling
Graft Rejection
/ diagnosis
Humans
Inflammation
/ diagnosis
Kidney
/ immunology
Kidney Transplantation
/ adverse effects
MicroRNAs
/ genetics
Prospective Studies
RNA, Messenger
/ genetics
RNA-Seq
Single-Cell Analysis
Systems Integration
Transcriptome
Treatment Outcome
antibody-mediated rejection
kidney transplantation
microRNA
microvascular inflammation
multi-omics
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
09
07
2021
accepted:
15
10
2021
entrez:
19
11
2021
pubmed:
20
11
2021
medline:
24
12
2021
Statut:
epublish
Résumé
In solid-organ transplantation, microRNAs (miRNAs) have emerged as key players in the regulation of allograft cells function in response to injury. To gain insight into the role of miRNAs in antibody-mediated rejection, a rejection phenotype histologically defined by microvascular inflammation, kidney allograft biopsies were subjected to miRNA but also messenger RNA (mRNA) profiling. Using a unique multistep selection process specific to the BIOMARGIN study (discovery cohort, N=86; selection cohort, N=99; validation cohort, N=298), six differentially expressed miRNAs were consistently identified: miR-139-5p (down) and miR-142-3p/150-5p/155-5p/222-3p/223-3p (up). Their expression level gradually correlated with microvascular inflammation intensity. The cell specificity of miRNAs target genes was investigated by integrating their
Identifiants
pubmed: 34795664
doi: 10.3389/fimmu.2021.738795
pmc: PMC8593247
doi:
Substances chimiques
MicroRNAs
0
RNA, Messenger
0
Types de publication
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
738795Informations de copyright
Copyright © 2021 Tinel, Lamarthée, Callemeyn, Van Loon, Sauvaget, Morin, Aouni, Rabant, Gwinner, Marquet, Naesens and Anglicheau.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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