Single-cell RNA Sequencing Reveals How the Aryl Hydrocarbon Receptor Shapes Cellular Differentiation Potency in the Mouse Colon.
Journal
Cancer prevention research (Philadelphia, Pa.)
ISSN: 1940-6215
Titre abrégé: Cancer Prev Res (Phila)
Pays: United States
ID NLM: 101479409
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
received:
16
08
2021
revised:
18
10
2021
accepted:
16
11
2021
pubmed:
25
11
2021
medline:
5
4
2022
entrez:
24
11
2021
Statut:
ppublish
Résumé
Despite recent progress recognizing the importance of aryl hydrocarbon receptor (Ahr)-dependent signaling in suppressing colon tumorigenesis, its role in regulating colonic crypt homeostasis remains unclear. To assess the effects of Ahr on intestinal epithelial cell heterogeneity and functional phenotypes, we utilized single-cell transcriptomics and advanced analytic strategies to generate a high-quality atlas for colonic intestinal crypts from wild-type and intestinal-specific Ahr knockout mice. Here we observed the promotive effects of Ahr deletion on
Identifiants
pubmed: 34815312
pii: 1940-6207.CAPR-21-0378
doi: 10.1158/1940-6207.CAPR-21-0378
pmc: PMC8741728
mid: NIHMS1759350
doi:
Substances chimiques
Receptors, Aryl Hydrocarbon
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
17-28Subventions
Organisme : NIEHS NIH HHS
ID : R01 ES025713
Pays : United States
Organisme : NCCIH NIH HHS
ID : R01 AT010282
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA202697
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES029067
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA197707
Pays : United States
Informations de copyright
©2021 American Association for Cancer Research.
Références
EMBO J. 2020 Oct 1;39(19):e104319
pubmed: 32915464
Science. 2015 Jan 2;347(6217):78-81
pubmed: 25554788
Nature. 2020 May;581(7808):303-309
pubmed: 32214235
Am J Physiol Gastrointest Liver Physiol. 2020 Mar 1;318(3):G451-G463
pubmed: 31905023
Cell Rep. 2021 Jan 26;34(4):108633
pubmed: 33503423
Science. 2020 Jan 24;367(6476):405-411
pubmed: 31974247
Bioinformatics. 2021 May 17;37(7):963-967
pubmed: 32840568
Curr Stem Cell Rep. 2020 Dec;6(4):109-118
pubmed: 34395177
Toxicol Sci. 2006 Jan;89(1):75-82
pubmed: 16192470
Science. 2017 Mar 24;355(6331):1330-1334
pubmed: 28336671
Bioinformatics. 2021 Jul 12;37(11):1528-1534
pubmed: 33244588
Nature. 2013 Nov 14;503(7475):218-23
pubmed: 24196716
Science. 2016 Apr 8;352(6282):189-96
pubmed: 27124452
Genome Biol. 2015 Dec 10;16:278
pubmed: 26653891
Patterns (N Y). 2020 Nov 05;1(9):100139
pubmed: 33336197
Science. 1997 May 23;276(5316):1268-72
pubmed: 9157888
Nature. 2018 Aug;560(7719):494-498
pubmed: 30089906
Immunol Cell Biol. 2014 May-Jun;92(5):460-5
pubmed: 24518984
Mol Cancer Res. 2019 Apr;17(4):929-936
pubmed: 30655325
Semin Cancer Biol. 2018 Oct;52(Pt 1):74-84
pubmed: 28855104
Nat Rev Cancer. 2018 Nov;18(11):669-680
pubmed: 30228301
Nat Biotechnol. 2020 Dec;38(12):1408-1414
pubmed: 32747759
Immunity. 2018 Aug 21;49(2):353-362.e5
pubmed: 30119997
Sci Rep. 2016 May 16;6:26069
pubmed: 27181744
BMC Bioinformatics. 2013 Apr 15;14:128
pubmed: 23586463
Nature. 2019 May;569(7754):121-125
pubmed: 31019301
Database (Oxford). 2019 Jan 1;2019:
pubmed: 30951143
Nature. 2009 Jan 29;457(7229):608-11
pubmed: 19092804
Autophagy. 2020 Aug;16(8):1436-1452
pubmed: 31775562
PLoS Comput Biol. 2020 Feb 25;16(2):e1007664
pubmed: 32097405
Elife. 2017 Dec 21;6:
pubmed: 29268862
Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13481-6
pubmed: 19651607
Mol Cancer Res. 2021 May;19(5):771-783
pubmed: 33495399
Stem Cell Reports. 2020 Jul 14;15(1):156-170
pubmed: 32531190
Cell Rep. 2016 Oct 25;17(5):1318-1329
pubmed: 27783946
Nat Commun. 2020 Aug 27;11(1):4307
pubmed: 32855414
Cell Stem Cell. 2020 Mar 5;26(3):377-390.e6
pubmed: 32084390
Nat Commun. 2021 Feb 17;12(1):1088
pubmed: 33597522
Cell Commun Signal. 2003 Oct 27;1(1):3
pubmed: 14613520
Ann Surg. 2016 Sep;264(3):429-36
pubmed: 27433903
Oncogene. 2005 Apr 18;24(17):2899-908
pubmed: 15838523
Nature. 2019 Mar;567(7746):49-55
pubmed: 30814735
PLoS One. 2012;7(2):e31686
pubmed: 22384056
Nat Commun. 2017 Jun 01;8:15599
pubmed: 28569836
Mol Nutr Food Res. 2021 Oct;65(20):e2100539
pubmed: 34406707
Nat Rev Drug Discov. 2018 Jun 28;17(7):470
pubmed: 29950706
PLoS Biol. 2020 Dec 11;18(12):e3001032
pubmed: 33306673
Gastroenterology. 2011 Jul;141(1):237-48, 248.e1
pubmed: 21600206
Bioinformatics. 2019 Nov 07;:
pubmed: 31697351
Methods Mol Biol. 2019;1935:125-139
pubmed: 30758824
Cell Mol Gastroenterol Hepatol. 2020;10(1):101-112
pubmed: 32004754
Cell. 2013 Jan 17;152(1-2):25-38
pubmed: 23273993
Nat Commun. 2020 Jan 17;11(1):334
pubmed: 31953387
Int J Exp Pathol. 2000 Apr;81(2):117-43
pubmed: 10762441
J Cell Mol Med. 2005 Jan-Mar;9(1):11-24
pubmed: 15784161
Nat Biotechnol. 2015 May;33(5):495-502
pubmed: 25867923