Adaptation, spread and transmission of SARS-CoV-2 in farmed minks and associated humans in the Netherlands.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
23 11 2021
23 11 2021
Historique:
received:
15
07
2021
accepted:
01
11
2021
entrez:
24
11
2021
pubmed:
25
11
2021
medline:
15
12
2021
Statut:
epublish
Résumé
In the first wave of the COVID-19 pandemic (April 2020), SARS-CoV-2 was detected in farmed minks and genomic sequencing was performed on mink farms and farm personnel. Here, we describe the outbreak and use sequence data with Bayesian phylodynamic methods to explore SARS-CoV-2 transmission in minks and humans on farms. High number of farm infections (68/126) in minks and farm workers (>50% of farms) were detected, with limited community spread. Three of five initial introductions of SARS-CoV-2 led to subsequent spread between mink farms until November 2020. Viruses belonging to the largest cluster acquired an amino acid substitution in the receptor binding domain of the Spike protein (position 486), evolved faster and spread longer and more widely. Movement of people and distance between farms were statistically significant predictors of virus dispersal between farms. Our study provides novel insights into SARS-CoV-2 transmission between mink farms and highlights the importance of combining genetic information with epidemiological information when investigating outbreaks at the animal-human interface.
Identifiants
pubmed: 34815406
doi: 10.1038/s41467-021-27096-9
pii: 10.1038/s41467-021-27096-9
pmc: PMC8611045
doi:
Substances chimiques
Spike Glycoprotein, Coronavirus
0
spike protein, SARS-CoV-2
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6802Subventions
Organisme : ZonMw (Netherlands Organisation for Health Research and Development)
ID : 10150062010005
Organisme : RCUK | Biotechnology and Biological Sciences Research Council (BBSRC)
ID : BBS/E/D/20002173
Informations de copyright
© 2021. The Author(s).
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