Gene Expression Profiling of Skeletal Muscles.
contraction
gene expression
metabolism
mouse
signaling
skeletal muscle
soleus
tibialis anterior
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
28 10 2021
28 10 2021
Historique:
received:
23
09
2021
revised:
21
10
2021
accepted:
27
10
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
17
2
2022
Statut:
epublish
Résumé
Next-generation sequencing provides an opportunity for an in-depth biocomputational analysis to identify gene expression patterns between soleus and tibialis anterior, two well-characterized skeletal muscles, and analyze their gene expression profiling. RNA read counts were analyzed for differential gene expression using the R package edgeR. Differentially expressed genes were filtered using a false discovery rate of less than 0.05 c, a fold-change value of more than twenty, and an association with overrepresented pathways based on the Reactome pathway over-representation analysis tool. Most of the differentially expressed genes associated with soleus are coded for components of lipid metabolism and unique contractile elements. Differentially expressed genes associated with tibialis anterior encoded mostly for glucose and glycogen metabolic pathway regulatory enzymes and calcium-sensitive contractile components. These gene expression distinctions partly explain the genetic basis for skeletal muscle specialization, and they may help to explain skeletal muscle susceptibility to disease and drugs and further refine tissue engineering approaches.
Identifiants
pubmed: 34828324
pii: genes12111718
doi: 10.3390/genes12111718
pmc: PMC8621074
pii:
doi:
Substances chimiques
Glycogen
9005-79-2
Glucose
IY9XDZ35W2
Types de publication
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAMS NIH HHS
ID : R01 AR054406
Pays : United States
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