Novel Mechanisms of Tumor Promotion by the Insulin Receptor Isoform A in Triple-Negative Breast Cancer Cells.
Animals
Carcinogenesis
/ metabolism
Cell Line, Tumor
Cell Movement
/ genetics
Cell Proliferation
/ genetics
Databases, Genetic
Female
Gene Expression Regulation, Neoplastic
Humans
Mice
Neoplasm Invasiveness
Neoplasm Metastasis
Neovascularization, Pathologic
/ genetics
Protein Isoforms
/ genetics
RNA-Seq
Receptor, Insulin
/ genetics
Survival Analysis
Transcriptome
/ genetics
Triple Negative Breast Neoplasms
/ blood supply
Zebrafish
IGF axis
breast cancer
hyperinsulinemia
insulin receptor isoform A
insulin receptor isoform transcriptome
insulin receptor isoforms
triple negative breast cancer
tumor promotion
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
12 11 2021
12 11 2021
Historique:
received:
27
07
2021
revised:
16
10
2021
accepted:
10
11
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
17
12
2021
Statut:
epublish
Résumé
The insulin receptor isoform A (IR-A) plays an increasingly recognized role in fetal growth and tumor biology in response to circulating insulin and/or locally produced IGF2. This role seems not to be shared by the IR isoform B (IR-B). We aimed to dissect the specific impact of IR isoforms in modulating insulin signaling in triple negative breast cancer (TNBC) cells. We generated murine 4T1 TNBC cells deleted from the endogenous insulin receptor (
Identifiants
pubmed: 34831367
pii: cells10113145
doi: 10.3390/cells10113145
pmc: PMC8621444
pii:
doi:
Substances chimiques
Protein Isoforms
0
Receptor, Insulin
EC 2.7.10.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : Start-Up Grant 21651 to ED, IG n. 23369 to AB and IG n. 21322 to MM
Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca
ID : PON RI FSE-FESR 2014-2020 to ALF
Organisme : PO-FESR Sicilia 2014-2020
ID : DiOncoGen: Innovative diagnostics to AF, ALF, AP, and SA.
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