Tubulin post-translational modifications in meiosis.

Tubulin / genetics Meiosis / genetics Spindle Apparatus / metabolism Chromosome Segregation Oocytes / metabolism Microtubules / metabolism Protein Processing, Post-Translational
Acetylation Chromosome segregation Meiosis Meiotic drive Oocyte Spindle Tubulin PTMs Tyrosination

Journal

Seminars in cell & developmental biology
ISSN: 1096-3634
Titre abrégé: Semin Cell Dev Biol
Pays: England
ID NLM: 9607332

Informations de publication

Date de publication:
15 03 2023
Historique:
received: 09 06 2021
revised: 22 10 2021
accepted: 14 11 2021
pmc-release: 15 03 2024
pubmed: 28 11 2021
medline: 30 11 2022
entrez: 27 11 2021
Statut: ppublish

Résumé

Haploid gametes are produced from diploid parents through meiosis, a process inherent to all sexually reproducing eukaryotes. Faithful chromosome segregation in meiosis is essential for reproductive success, although it is less clear how the meiotic spindle achieves this compared to the mitotic spindle. It is becoming increasingly clear that tubulin post-translational modifications (PTMs) play critical roles in regulating microtubule functions in many biological processes, and meiosis is no exception. Here, I review recent advances in the understanding of tubulin PTMs in meiotic spindles, especially focusing on their roles in spindle integrity, oocyte aging, and non-Mendelian transmission.

Identifiants

DOI: 10.1016/j.semcdb.2021.11.014 PMID: 34836784 PMC: PMC9124733
pubmed: 34836784
pii: S1084-9521(21)00290-1
doi: 10.1016/j.semcdb.2021.11.014
pmc: PMC9124733
mid: NIHMS1759606
pii:
doi:

Substances chimiques

Tubulin 0

Types de publication

Journal Article Review Research Support, N.I.H., Intramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

38-45

Subventions

Organisme : Intramural NIH HHS
ID : ZIA HL006249
Pays : United States

Informations de copyright

Published by Elsevier Ltd.

Déclaration de conflit d'intérêts

Conflict of interest The author declare no conflicts of interest.

Auteurs

Takashi Akera (T)

Cell and Developmental Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda 20892, MD, USA. Electronic address: takashi.akera@nih.gov.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Tubuline › Tubulin post-translational modifications in meiosis.
questionsmedicales.fr › Phénomènes génétiques › Division du noyau cellulaire › Méiose › Tubulin post-translational modifications in meiosis.
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Cytosquelette › Appareil du fuseau › Tubulin post-translational modifications in meiosis.
questionsmedicales.fr › Phénomènes génétiques › Division du noyau cellulaire › Ségrégation des chromosomes › Tubulin post-translational modifications in meiosis.
questionsmedicales.fr › Cellules › Cellules germinales › Ovocytes › Tubulin post-translational modifications in meiosis.
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Cytosquelette › Microtubules › Tubulin post-translational modifications in meiosis.
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Modification traductionnelle des protéines › Maturation post-traductionnelle des protéines › Tubulin post-translational modifications in meiosis.