Recent advancement of decellularization extracellular matrix for tissue engineering and biomedical application.
biomedical applications
decellularization
decellularized extracellular matrix
regenerative medicine
tissue engineering
Journal
Artificial organs
ISSN: 1525-1594
Titre abrégé: Artif Organs
Pays: United States
ID NLM: 7802778
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
revised:
18
10
2021
received:
20
08
2021
accepted:
15
11
2021
pubmed:
3
12
2021
medline:
5
4
2022
entrez:
2
12
2021
Statut:
ppublish
Résumé
Decellularized extracellular matrixs (dECMs) derived from organs and tissues have emerged as a promising tool, as they encompass the characteristics of an ideal tissue scaffold: complex composition, vascular networks and unique tissue-specific architecture. Consequently, their use has propagated throughout tissue engineering and regenerative medicine. dECM can be easily obtained from various tissues/organs by appropriate decellularization protocolsand is entitled to provide necessary cues to cells homing. In this review, we describe the decellularization and sterilization methods that are commonly used in recent research, the effects of these methods upon biologic scaffold material are discussed. Also, we summarize the recent developments of recellularization and vascularization techniques in regeneration medicine. Additionally, dECM preservation methods is mentioned, which provides the basis for the establishment of organ bank. Biomedical applications and the status of current research developments relating to dECM biomaterials are outlined, including transplantation in vivo, disease models and drug screening, organoid, 3D bioprinting, tissue reconstruction and rehabilitation and cell transplantation and culture. Finally, critical challenges and future developing technologies are discussed. With the development of tissue engineering and regenerative medicine, dECM will have broader applications in the field of biomedicine in the near future.
Sections du résumé
BACKGROUND
BACKGROUND
Decellularized extracellular matrixs (dECMs) derived from organs and tissues have emerged as a promising tool, as they encompass the characteristics of an ideal tissue scaffold: complex composition, vascular networks and unique tissue-specific architecture. Consequently, their use has propagated throughout tissue engineering and regenerative medicine. dECM can be easily obtained from various tissues/organs by appropriate decellularization protocolsand is entitled to provide necessary cues to cells homing.
METHODS
METHODS
In this review, we describe the decellularization and sterilization methods that are commonly used in recent research, the effects of these methods upon biologic scaffold material are discussed. Also, we summarize the recent developments of recellularization and vascularization techniques in regeneration medicine. Additionally, dECM preservation methods is mentioned, which provides the basis for the establishment of organ bank.
RESULTS
RESULTS
Biomedical applications and the status of current research developments relating to dECM biomaterials are outlined, including transplantation in vivo, disease models and drug screening, organoid, 3D bioprinting, tissue reconstruction and rehabilitation and cell transplantation and culture. Finally, critical challenges and future developing technologies are discussed.
CONCLUSIONS
CONCLUSIONS
With the development of tissue engineering and regenerative medicine, dECM will have broader applications in the field of biomedicine in the near future.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
549-567Subventions
Organisme : National Natural Science Foundation of China
ID : 51576132
Organisme : National Natural Science Foundation of China
ID : 52076140
Organisme : National Major Science and Technology Project of China
ID : 2018ZX10734404
Informations de copyright
© 2021 International Center for Artificial Organs and Transplantation and Wiley Periodicals LLC.
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