Parallel artificial liquid membrane extraction of organophosphorus nerve agent degradation products from environmental samples.

An emerging miniaturized high-throughput microextraction technique named Parallel artificial liquid membrane extraction (PALME) was, for the first time, investigated for the extraction of polar alkyl methylphosphonic acids (AMPAs) that are the degradation products of organophosphorus nerve agents. The effect of the key-parameters of the extraction method (nature of the membrane, of the extraction solvent, of the pH values of both donor and acceptor phases, agitation speed, extraction time, temperature and ionic strength) on the extraction recoveries was studied in spiked pure water samples. This led to extraction recoveries in the range of 25-102% for the 5 targeted analytes from water with enrichment factors in the range of 4.50-42.75. The developed PALME-LC-MS/MS method was first evaluated with spiked pure water. LOQs (S/N ≥ 10) were in the range of 0.009-1.141 ng mL

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Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.