Reciprocal regulation of chaperone-mediated autophagy and the circadian clock.


Journal

Nature cell biology
ISSN: 1476-4679
Titre abrégé: Nat Cell Biol
Pays: England
ID NLM: 100890575

Informations de publication

Date de publication:
12 2021
Historique:
received: 14 08 2020
accepted: 22 10 2021
pubmed: 9 12 2021
medline: 24 2 2022
entrez: 8 12 2021
Statut: ppublish

Résumé

Circadian rhythms align physiological functions with the light-dark cycle through oscillatory changes in the abundance of proteins in the clock transcriptional programme. Timely removal of these proteins by different proteolytic systems is essential to circadian strength and adaptability. Here we show a functional interplay between the circadian clock and chaperone-mediated autophagy (CMA), whereby CMA contributes to the rhythmic removal of clock machinery proteins (selective chronophagy) and to the circadian remodelling of a subset of the cellular proteome. Disruption of this autophagic pathway in vivo leads to temporal shifts and amplitude changes of the clock-dependent transcriptional waves and fragmented circadian patterns, resembling those in sleep disorders and ageing. Conversely, loss of the circadian clock abolishes the rhythmicity of CMA, leading to pronounced changes in the CMA-dependent cellular proteome. Disruption of this circadian clock/CMA axis may be responsible for both pathways malfunctioning in ageing and for the subsequently pronounced proteostasis defect.

Identifiants

pubmed: 34876687
doi: 10.1038/s41556-021-00800-z
pii: 10.1038/s41556-021-00800-z
pmc: PMC8688252
mid: NIHMS1750705
doi:

Substances chimiques

ARNTL Transcription Factors 0
Bmal1 protein, mouse 0
Lysosomal-Associated Membrane Protein 2 0
Proteome 0
CLOCK Proteins EC 2.3.1.48

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1255-1270

Subventions

Organisme : NIA NIH HHS
ID : R01 AG021904
Pays : United States
Organisme : NICHD NIH HHS
ID : P50 HD105354
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG043517
Pays : United States
Organisme : NIA NIH HHS
ID : R37 AG021904
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007491
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG054108
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG038072
Pays : United States
Organisme : NICHD NIH HHS
ID : U54 HD086984
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL144456
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI113919
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK020541
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK098408
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007288
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG043517
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG031782
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

© 2021. The Author(s), under exclusive licence to Springer Nature Limited.

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Auteurs

Yves R Juste (YR)

Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA.
Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY, USA.

Susmita Kaushik (S)

Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA.
Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY, USA.

Mathieu Bourdenx (M)

Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA.
Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY, USA.

Ranee Aflakpui (R)

Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA.

Sanmay Bandyopadhyay (S)

Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA.

Fernando Garcia (F)

Proteomic Unit, Spanish National Cancer Research Center (CNIO) Proteored-ISCIII, Madrid, Spain.

Antonio Diaz (A)

Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA.
Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY, USA.

Kristen Lindenau (K)

Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA.
Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY, USA.

Vincent Tu (V)

Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA.

Gregory J Krause (GJ)

Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA.
Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY, USA.

Maryam Jafari (M)

Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA.
Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY, USA.

Rajat Singh (R)

Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA.
Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY, USA.
Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.

Javier Muñoz (J)

Proteomic Unit, Spanish National Cancer Research Center (CNIO) Proteored-ISCIII, Madrid, Spain.
Biocruces Bizkaia Health Research Institute, Barakaldo, Spain.
Ikerbasque, Basque Foundation for Science, Bilbao, Spain.

Fernando Macian (F)

Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY, USA.
Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA.

Ana Maria Cuervo (AM)

Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA. ana-maria.cuervo@einsteinmed.org.
Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY, USA. ana-maria.cuervo@einsteinmed.org.
Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA. ana-maria.cuervo@einsteinmed.org.

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