Discovery of an ancient MHC category with both class I and class II features.
Amino Acid Sequence
Animals
Cluster Analysis
Evolution, Molecular
Fishes
/ classification
Histocompatibility Antigens
/ chemistry
Histocompatibility Antigens Class I
/ chemistry
Histocompatibility Antigens Class II
/ chemistry
Humans
Major Histocompatibility Complex
/ genetics
Multigene Family
Phylogeny
Protein Domains
Protein Multimerization
Vertebrates
/ classification
MHC class I
MHC class II
MHC class divergence
major histocompatibility complex
molecular evolution
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
21 12 2021
21 12 2021
Historique:
accepted:
02
11
2021
entrez:
14
12
2021
pubmed:
15
12
2021
medline:
14
1
2022
Statut:
ppublish
Résumé
Two classes of major histocompatibility complex (MHC) molecules, MHC class I and class II, play important roles in our immune system, presenting antigens to functionally distinct T lymphocyte populations. However, the origin of this essential MHC class divergence is poorly understood. Here, we discovered a category of MHC molecules (W-category) in the most primitive jawed vertebrates, cartilaginous fish, and also in bony fish and tetrapods. W-category, surprisingly, possesses class II-type α- and β-chain organization together with class I-specific sequence motifs for interdomain binding, and the W-category α2 domain shows unprecedented, phylogenetic similarity with β
Identifiants
pubmed: 34903649
pii: 2108104118
doi: 10.1073/pnas.2108104118
pmc: PMC8713811
pii:
doi:
Substances chimiques
Histocompatibility Antigens
0
Histocompatibility Antigens Class I
0
Histocompatibility Antigens Class II
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2021 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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