Enhancement of Proton Therapy Efficiency by Noble Metal Nanoparticles Is Driven by the Number and Chemical Activity of Surface Atoms.
Monte Carlo models
cancer treatments
fluorescent radical detectors
laser ablation in liquids
surfactant-free nanoparticles
Journal
Small (Weinheim an der Bergstrasse, Germany)
ISSN: 1613-6829
Titre abrégé: Small
Pays: Germany
ID NLM: 101235338
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
revised:
18
11
2021
received:
20
10
2021
pubmed:
19
12
2021
medline:
5
4
2022
entrez:
18
12
2021
Statut:
ppublish
Résumé
Proton-based radiotherapy is a modern technique for the treatment of solid tumors with significantly reduced side effects to adjacent tissues. Biocompatible nanoparticles (NPs) with high atomic numbers are known to serve as sensitizers and to enhance treatment efficacy, which is commonly believed to be attributed to the generation of reactive oxygen species (ROS). However, little systematic knowledge is available on how either physical effects due to secondary electron generation or the particle surface chemistry affect ROS production. Thereto, ligand-free colloidal platinum (Pt) and gold (Au) NPs with well-controlled particle size distributions and defined total surface area are proton-irradiated. A fluorescence-based assay is developed to monitor the formation of ROS using terephthalic acid as a cross-effect-free dye. The findings indicate that proton irradiation (PI)-induced ROS formation sensitized by noble metal NPs is driven by the total available particle surface area rather than particle size or mass. Furthermore, a distinctive material effect with Pt being more active than Au is observed which clearly indicates that the chemical reactivity of the NP surface is a main contributor to ROS generation upon PI. These results pave the way towards an in-depth understanding of the NP-induced sensitizing effects upon PI and hence a well-controlled enhanced therapy.
Identifiants
pubmed: 34921500
doi: 10.1002/smll.202106383
doi:
Substances chimiques
Platinum
49DFR088MY
Gold
7440-57-5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2106383Informations de copyright
© 2021 The Authors. Small published by Wiley-VCH GmbH.
Références
C. Sicard-Roselli, E. Brun, M. Gilles, G. Baldacchino, C. Kelsey, H. McQuaid, C. Polin, N. Wardlow, F. Currell, Small 2014, 10, 3338.
A. Kim, C. Yonemoto, C. P. Feliciano, B. Shashni, Y. Nagasaki, Small 2021, 17, 2008210.
D. Luo, X. Wang, S. Zeng, G. Ramamurthy, C. Burda, J. P. Basilion, Small 2019, 15, 1900968.
S. Klein, M. Kızaloğlu, L. Portilla, H. Park, T. Rejek, J. Hümmer, K. Meyer, R. Hock, L. V. R. Distel, M. Halik, C. Kryschi, Small 2018, 14, 1704111.
I. Miladi, C. Alric, S. Dufort, P. Mowat, A. Dutour, C. Mandon, G. Laurent, E. Bräuer-Krisch, N. Herath, J.-L. Coll, M. Dutreix, F. Lux, R. Bazzi, C. Billotey, M. Janier, P. Perriat, G. L. Duc, S. Roux, O. Tillement, Small 2014, 10, 1116.
J. Du, Z. Gu, L. Yan, Y. Yong, X. Yi, X. Zhang, J. Liu, R. Wu, C. Ge, C. Chen, Y. Zhao, Adv. Mater. 2017, 29, 1701268.
W. Fan, B. Yung, P. Huang, X. Chen, Chem. Rev. 2017, 117, 13566.
B. Yang, Y. Chen, J. Shi, Chem. Rev. 2019, 119, 4881.
G. Song, L. Cheng, Y. Chao, K. Yang, Z. Liu, Adv. Mater. 2017, 29, 1700996.
J. Choi, G. Kim, S. B. Cho, H.-J. Im, J. Nanobiotechnol. 2020, 18, 122.
J. F. Hainfeld, D. N. Slatkin, H. M. Smilowitz, Phys. Med. Biol. 2004, 49, N309.
J. F. Hainfeld, D. N. Slatkin, (Nanoprobes, Inc.), US6955639B2, 2004.
J. S. Loeffler, M. Durante, Nat. Rev. Clin. Oncol. 2013, 10, 411.
D. Schardt, T. Elsässer, D. Schulz-Ertner, Rev. Mod. Phys. 2010, 82, 383.
B. Timmermann, Klin. Padiatr. 2010, 222, 127.
S. Lacombe, E. Porcel, E. Scifoni, Cancer Nanotechnol. 2017, 8, 9.
K.-H. Kim, H.-T. Kim, J.-H. Kim, S.-J. Seo, D.-S. Chung, J.-K. Kim, Int. J. PIXE 2009, 19, 143.
J.-K. Kim, S.-J. Seo, K.-H. Kim, T.-J. Kim, M.-H. Chung, K.-R. Kim, T.-K. Yang, Nanotechnology 2010, 21, 425102.
C.-J. Liu, C.-H. Wang, S.-T. Chen, H.-H. Chen, W.-H. Leng, C.-C. Chien, C.-L. Wang, I. M. Kempson, Y. Hwu, T.-C. Lai, M. Hsiao, C.-S. Yang, Y.-J. Chen, G. Margaritondo, Phys. Med. Biol. 2010, 55, 931.
R. Schulte, (Knobbe Martens Olson & Bear, LLP), US 20070031337, 2005.
R. Schulte, V. Bashkirov, T. Li, Z. Liang, H.-W. Sadrozinski, D. C. Williams, 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano 2004, p. 1354.
G. Dollinger, Nanotechnology 2011, 22, 248001, discussion 248002.
C. Wälzlein, E. Scifoni, M. Krämer, M. Durante, Phys. Med. Biol. 2014, 59, 1441.
J. C. Polf, L. F. Bronk, W. H. P. Driessen, W. Arap, R. Pasqualini, M. Gillin, App. Phys. Lett. 2011, 98, 193702.
H. H. Binder, Lexikon der chemischen Elemente das Periodensystem in Fakten, Zahlen und Daten; mit vielen tabellarischen Zusammenstellungen, Hirzel, Stuttgart 1999.
R. Ahmad, G. Royle, A. Lourenço, M. Schwarz, F. Fracchiolla, K. Ricketts, Phys. Med. Biol. 2016, 61, 4537.
J. Cho, C. Gonzalez-Lepera, N. Manohar, M. Kerr, S. Krishnan, S. H. Cho, Phys. Med. Biol. 2016, 61, 2562.
S. Li, S. Penninckx, L. Karmani, A.-C. Heuskin, K. Watillon, R. Marega, J. Zola, V. Corvaglia, G. Genard, B. Gallez, O. Feron, P. Martinive, D. Bonifazi, C. Michiels, S. Lucas, Nanotechnology 2016, 27, 455101.
T. Schlathölter, P. Eustache, E. Porcel, D. Salado, L. Stefancikova, O. Tillement, F. Lux, P. Mowat, A. K. Biegun, M.-J. van Goethem, H. Remita, S. Lacombe, Int. J. Nanomed. 2016, 11, 1549.
H. N. Tran, M. Karamitros, V. N. Ivanchenko, S. Guatelli, S. McKinnon, K. Murakami, T. Sasaki, S. Okada, M. C. Bordage, Z. Francis, Z. El Bitar, M. A. Bernal, J. I. Shin, S. B. Lee, P. Barberet, T. T. Tran, J. Brown, T. V. N. Hao, S. Incerti, Nucl. Instrum. Methods Phys. Res., Sect. B 2016, 373, 126.
J.-K. Jeon, S.-M. Han, S.-K. Min, S.-J. SEO, K. Ihm, W.-S. Chang, J.-K. Kim, Sci. Rep. 2016, 6, 37848.
S. Li, S. Bouchy, S. Penninckx, R. Marega, O. Fichera, B. Gallez, O. Feron, P. Martinive, A.-C. Heuskin, C. Michiels, S. Lucas, Nanomedicine 2019, 14, 317.
C. L. Smith, T. Ackerly, S. P. Best, F. Gagliardi, K. Kie, P. J. Little, G. McCorkell, C. A. Sale, Y. Tsunei, T. Tominaga, S. S. Volaric, M. Geso, Radiat. Meas. 2015, 82, 122.
W.-J. Lin, T.-S. Duh, W.-M. Li, M.-H. Li, (Institute of Nuclear Energy Research), US9468608B2, 2016.
D. Peukert, I. Kempson, M. Douglass, E. Bezak, Int. J. Mol. Sci. 2019, 20, 4280.
D. Trachootham, W. Lu, M. A. Ogasawara, N. Rivera-Del Valle, P. Huang, Antioxid. Redox Signaling 2008, 10, 1343.
J. Gao, Y. Zheng, Int. J. Cancer Ther. Oncol. 2014, 2, 02025.
S. McKinnon, S. Guatelli, S. Incerti, V. Ivanchenko, K. Konstantinov, S. Corde, M. Lerch, M. Tehei, A. Rosenfeld, Phys. Med. 2016, 32, 1584.
D. Zhang, B. Gökce, S. Barcikowski, Chem. Rev. 2017, 117,3990.
C.-Y. Shih, C. Chen, C. Rehbock, A. Tymoczko, U. Wiedwald, M. Kamp, U. Schuermann, L. Kienle, S. Barcikowski, L. V. Zhigilei, J. Phys. Chem. C 2021, 125, 2132.
C.-Y. Shih, M. V. Shugaev, C. Wu, L. V. Zhigilei, Phys. Chem. Chem. Phys. 2020, 22, 7077.
F. Waag, Y. Li, A. R. Ziefuß, E. Bertin, M. Kamp, V. Duppel, G. Marzun, L. Kienle, S. Barcikowski, B. Gökce, RSC Adv. 2019, 9, 18547.
A. R. Ziefuß, S. Reich, S. Reichenberger, M. Levantino, A. Plech, Phys. Chem. Chem. Phys. 2020, 22, 4993.
A. R. Ziefuß, S. Reichenberger, C. Rehbock, I. Chakraborty, M. Gharib, W. J. Parak, S. Barcikowski, J. Phys. Chem. C 2018, 122, 22125.
F. Waag, B. Gökce, C. Kalapu, G. Bendt, S. Salamon, J. Landers, U. Hagemann, M. Heidelmann, S. Schulz, H. Wende, N. Hartmann, M. Behrens, S. Barcikowski, Sci. Rep. 2017, 7, 13161.
S. Siebeneicher, F. Waag, M. E. Castillo, V. V. Shvartsman, D. C. Lupascu, B. Gökce, Nanomaterials 2020, 10, 359.
A. R. Ziefuß, S. Barcikowski, C. Rehbock, Langmuir 2019, 35, 6630.
V. Amendola, D. Amans, Y. Ishikawa, N. Koshizaki, S. Scirè, G. Compagnini, S. Reichenberger, S. Barcikowski, Chem. - Eur. J. 2020, 26, 9206.
A. Pyatenko, H. Wang, N. Koshizaki, T. Tsuji, Laser Photonics Rev. 2013, 7, 596.
O. Rocha-Rocha, M. Cortez-Valadez, R. García-Llamas, G. Calderón-Ayala, P. G. Maní-González, M. Flores-Acosta, J. Electron. Mater. 2021, 50, 4850.
A. G. Georgakilas, Mol. BioSyst. 2008, 4, 30.
J. F. Ward, Prog. Nucleic Acid Res. Mol. Biol. 1988, 35, 95.
A. G. Georgakilas, P. O'Neill, R. D. Stewart, Radiat. Res. 2013, 180, 100.
G. Louit, M. Hanedanian, F. Taran, H. Coffigny, J. P. Renault, S. Pin, Analyst 2009, 134, 250.
P. K. Chattopadhyay, B. Gaylord, A. Palmer, N. Jiang, M. A. Raven, G. Lewis, M. A. Reuter, A. K. M. Nur-ur Rahman, D. A. Price, M. R. Betts, M. Roederer, Cytometry, Part A 2012, 81, 456.
L. Cisse, A. Djande, M. Capo-Chichi, A. Khonté, J.-P. Bakhoum, F. Delattre, J. Yoda, A. Saba, A. Tine, J.-J. Aaron, J. Phys. Org. Chem. 2020, 33, e4014.
M. Price, J. J. Reiners, A. M. Santiago, D. Kessel, J. Photochem. Photobiol., C 2009, 85, 1177.
T. F. Scientific, Fluorescence Response of 3′-(p-aminophenyl) Fluorescein (APF), 3′-(p-Hydroxyphenyl) Fluorescein (HPF) and Dichlorodihydrofluorescein Diacetate (H2DCFDA) to Various Reactive Oxygen Species (ROS)-Table 18.4, https://www.thermofisher.com/de/de/home/references/molecular-probes-the-handbook/tables/fluorescence-response-of-3-p-aminophenyl-fluorescein-apf-3-p-hydroxyphenyl-fluorescein-hpf-and-dichlorodihydrofluorescein-diacetate-h2dcfda-to-various-reactive-oxygen-species-ros.html (accessed: November 2021).
S. Eremia, D. Chevalierlucia, G. Radu, J. Marty, Talanta 2008, 77, 858.
D. H. Gonzalez, X. M. Kuang, J. A. Scott, G. O. Rocha, S. E. Paulson, Anal. Lett. 2018, 51, 2488.
E. Jimenez-Relinque, M. Castellote, Cem. Concr. Res. 2015, 74, 108.
R. W. Matthews, Radiat. Res. 1980, 83, 27.
J. C. Barreto, G. S. Smith, N. H. Strobel, P. A. McQuillin, T. A. Miller, Life Sci. 1994, 56, PL89.
K. D. Dobson, A. McQuillan, Spectrochim. Acta, Part A 2000, 56, 557.
M. Fischer, J. Hormes, G. Marzun, P. Wagener, U. Hagemann, S. Barcikowski, Langmuir 2016, 32, 8793.
S. Petersen, S. Barcikowski, J. Phys. Chem. C 2009, 113, 19830.
E. Dulkeith, A. C. Morteani, T. Niedereichholz, T. A. Klar, J. Feldmann, S. A. Levi, F. C. J. M. van Veggel, D. N. Reinhoudt, M. Möller, D. I. Gittins, Phys. Rev. Lett. 2002, 89, 203002.
M. Sotiropoulos, N. T. Henthorn, J. W. Warmenhoven, R. I. Mackay, K. J. Kirkby, M. J. Merchant, Nanoscale 2017, 9, 18413.
S. Agostinelli, J. Allison, K. Amako, J. Apostolakis, H. Araujo, P. Arce, M. Asai, D. Axen, S. Banerjee, G. Barrand, F. Behner, L. Bellagamba, J. Boudreau, L. Broglia, A. Brunengo, H. Burkhardt, S. Chauvie, J. Chuma, R. Chytracek, G. Cooperman, G. Cosmo, P. Degtyarenko, A. Dell'Acqua, G. Depaola, D. Dietrich, R. Enami, A. Feliciello, C. Ferguson, H. Fesefeldt, G. Folger, et al., Nucl. Instrum. Methods Phys. Res., Sect. A 2003, 506, 250.
F. Hespeels, A. C. Heuskin, E. Scifoni, M. Kraemer, S. Lucas, Nucl. Instrum. Methods Phys. Res., Sect. B 2017, 401, 8.
M. Krämer, Nucl. Instrum. Methods Phys. Res., Sect. B 1995, 105, 14.
A. V. Verkhovtsev, A. V. Korol, A. V. Solov'yov, J. Phys. Chem. C 2015, 119, 11000.
Y. Lin, S. J. McMahon, H. Paganetti, J. Schuemann, Phys. Med. Biol. 2015, 60, 4149.
I. Martínez-Rovira, Y. Prezado, Med. Phys. 2015, 42, 6703.
M. C. Fuss, D. Boscolo, M. Durante, E. Scifoni, M. Krämer, Phys. Med. Biol. 2020, 65, 075008.
S. Incerti, G. Baldacchino, M. Bernal, R. Capra, C. Champion, Z. Francis, P. Guèye, A. Mantero, B. Mascialino, P. Moretto, P. Nieminen, C. Villagrasa, C. Zacharatou, Int. J. Model., Simul., Sci. Comput. 2010, 01, 157.
D. Boscolo, M. Krämer, M. Durante, M. C. Fuss, E. Scifoni, Chem. Phys. Lett. 2018, 698, 11.
S. J. Soenen, B. Manshian, J. M. Montenegro, F. Amin, B. Meermann, T. Thiron, M. Cornelissen, F. Vanhaecke, S. Doak, W. J. Parak, S. de Smedt, K. Braeckmans, ACS Nano 2012, 6, 5767.
H. Gehrke, J. Pelka, C. G. Hartinger, H. Blank, F. Bleimund, R. Schneider, D. Gerthsen, S. Bräse, M. Crone, M. Türk, D. Marko, Arch. Toxicol. 2011, 85, 799.
S. Behzadi, V. Serpooshan, W. Tao, M. A. Hamaly, M. Y. Alkawareek, E. C. Dreaden, D. Brown, A. M. Alkilany, O. C. Farokhzad, M. Mahmoudi, Chem. Soc. Rev. 2017, 46, 4218.
L. Gamrad, C. Rehbock, J. Krawinkel, B. Tumursukh, A. Heisterkamp, S. Barcikowski, J. Phys. Chem. C 2014, 118, 10302.
A. F. Haque, M. M. Haque, S. Sultana, M. A. R. Patoary, M. S. Hossain, M. Maaza, M. A. Uddin, Results Phys. 2019, 15, 102519.
I. Plante, F. A. Cucinotta, New J. Phys. 2009, 11, 063047.
J. R. Sabin, J. Oddershede, S. P. Sauer, Adv. Quantum Chem. 2013, 65, 63.
The International Commission on Radiation Units and Measurements J. ICRU 2014, 14, ICRU Report No. 90.
J. E. Reutt, L. S. Wang, Y. T. Lee, D. A. Shirley, J. Chem. Phys. 1986, 85, 6928.
S. J. Perkins, Eur. J. Biochem. 1986, 157, 169.
T. Jahnke, H. Sann, T. Havermeier, K. Kreidi, C. Stuck, M. Meckel, M. Schöffler, N. Neumann, R. Wallauer, S. Voss, A. Czasch, O. Jagutzki, A. Malakzadeh, F. Afaneh, T. Weber, H. Schmidt-Böcking, R. Dörner, Nat. Phys. 2010, 6, 139.
J.-K. Kim, S.-J. Seo, H.-T. Kim, K.-H. Kim, M.-H. Chung, K.-R. Kim, S.-J. Ye, Phys. Med. Biol. 2012, 57, 8309.
D. Peukert, I. Kempson, M. Douglass, E. Bezak, Phys. Med. 2018, 47, 121.
Z. Kuncic, S. Lacombe, Phys. Med. Biol. 2018, 63, 02TR01.
D. R. Lide, CRC Handbook of Chemistry and Physics: A Ready-Reference Book of Chemical and Physical Data, CRC Press, Boca Raton 2003.
W. Lotz, J. Opt. Soc. Am. 1970, 60, 206.
D. R. Lide, CRC Handbook of Chemistry and Physics, 81st ed., A Ready-Reference Book of Chemical and Physical Data (Student Edition), CRC Press, Boca Raton 2000.
M. Kajita, K. Hikosaka, M. Iitsuka, A. Kanayama, N. Toshima, Y. Miyamoto, Free Radic. Res. 2007, 41, 615.
J. A. Dean, Lange's Handbook of Chemistry, McGraw-Hill, New York 1999.
M.-R. Kalus, R. Lanyumba, N. Lorenzo-Parodi, M. A. Jochmann, K. Kerpen, U. Hagemann, T. C. Schmidt, S. Barcikowski, B. Gökce, Phys. Chem. Chem. Phys. 2019, 21, 18636.
M. Shilo, M. Motiei, P. Hana, R. Popovtzer, Nanoscale 2014, 6, 2146.