The triterpenoids and sesquiterpenoids from the plant of Agrimonia pilosa.

Agrimonia / chemistry Glycoside Hydrolase Inhibitors / chemistry Magnetic Resonance Spectroscopy Optical Rotation Sesquiterpenes / chemistry Spectrophotometry, Infrared Spectrophotometry, Ultraviolet Triterpenes / chemistry
Agrimonia pilosa Cytotoxicity Nortriterpenoid Sesquiterpenoid Structural elucidation

Journal

Fitoterapia
ISSN: 1873-6971
Titre abrégé: Fitoterapia
Pays: Netherlands
ID NLM: 16930290R

Informations de publication

Date de publication:
Mar 2022
Historique:
received: 18 11 2021
revised: 13 12 2021
accepted: 13 12 2021
pubmed: 20 12 2021
medline: 18 3 2022
entrez: 19 12 2021
Statut: ppublish

Résumé

A phytochemistry of the whole plant of Agrimonia pilosa led to the discovery of two new nortriterpenoids, agrimonorterpenes A and B (1 and 2), together with one known triterpenoid fupenzic acid (3) and seven known sesquiterpenoids (4-10). The new structures were determined as 19α-hydroxy-2-oxo-nor-A (3)-urs-11,12-dien-28-oic acid (1) and 2, 19β-dihydroxy-3-oxo-23-noroleana-1, 4, 12-trien-28-oic acid (2) by the spectroscopic data of UV, IR, HR-ESI-MS, and NMR. Notably, the structure of 1 possessed a rare five-membered A- ring. And this is the first time to discover the sesquiterpenoids (4-10) from A. pilosa. Compound 3 displayed the selective cytotoxicity against HCT116, BGC823, and HepG2 cell lines with the IC

Identifiants

DOI: 10.1016/j.fitote.2021.105104 PMID: 34923054
pubmed: 34923054
pii: S0367-326X(21)00279-3
doi: 10.1016/j.fitote.2021.105104
pii:
doi:

Substances chimiques

Glycoside Hydrolase Inhibitors 0
Sesquiterpenes 0
Triterpenes 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

105104

Informations de copyright

Copyright © 2021 Elsevier B.V. All rights reserved.

Auteurs

Jia Zhang (J)

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China.

Ya-Nan Yang (YN)

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China.

Zi-Ming Feng (ZM)

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China.

Xiang Yuan (X)

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China.

Xu Zhang (X)

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China.

Jian-Shuang Jiang (JS)

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China. Electronic address: jiangjs@imm.ac.cn.

Pei-Cheng Zhang (PC)

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China. Electronic address: pczhang@imm.ac.cn.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Rosanae › Rosales › Rosaceae › Agrimonia › The triterpenoids and sesquiterpenoids from...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hypoglycémiants › Inhibiteurs des glycoside hydrolases › The triterpenoids and sesquiterpenoids from...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectroscopie par résonance magnétique › The triterpenoids and sesquiterpenoids from...
questionsmedicales.fr › Phénomènes physiques › Phénomènes optiques › Pouvoir rotatoire › The triterpenoids and sesquiterpenoids from...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Sesquiterpènes › The triterpenoids and sesquiterpenoids from...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectrophotométrie › Spectrophotométrie IR › The triterpenoids and sesquiterpenoids from...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectrophotométrie › Spectrophotométrie UV › The triterpenoids and sesquiterpenoids from...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Triterpènes › The triterpenoids and sesquiterpenoids from...