Enhanced Triplex Hybridization of DNA and RNA via Syndiotactic Side Chain Presentation in Minimal bPNAs.


Journal

Biochemistry
ISSN: 1520-4995
Titre abrégé: Biochemistry
Pays: United States
ID NLM: 0370623

Informations de publication

Date de publication:
18 01 2022
Historique:
pubmed: 28 12 2021
medline: 19 2 2022
entrez: 27 12 2021
Statut: ppublish

Résumé

General design principles for recognition at noncanonical interfaces of DNA and RNA remain elusive. Triplex hybridization of bifacial peptide nucleic acids (bPNAs) with oligo-T/U DNAs and RNAs is a robust recognition platform that can be used to define structure-function relationships in synthetic triplex formation. To this end, a set of minimal (

Identifiants

pubmed: 34955016
doi: 10.1021/acs.biochem.1c00693
pmc: PMC9361178
mid: NIHMS1824278
doi:

Substances chimiques

Peptide Nucleic Acids 0
Uracil 56HH86ZVCT
RNA 63231-63-0
DNA 9007-49-2
Thymine QR26YLT7LT

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

85-91

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM111995
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM143543
Pays : United States

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Auteurs

Sarah Rundell (S)

Department of Chemistry & Biochemistry, The Ohio State University, 100 W. 18th Avenue, Columbus, Ohio 43210, United States.

Oliver Munyaradzi (O)

Department of Chemistry & Biochemistry, The Ohio State University, 100 W. 18th Avenue, Columbus, Ohio 43210, United States.

Dennis Bong (D)

Department of Chemistry & Biochemistry, The Ohio State University, 100 W. 18th Avenue, Columbus, Ohio 43210, United States.

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Classifications MeSH