The Effect of Gene Mutations on Metastasis and Overall Survival in Metastatic and Nonmetastatic Colon Cancers.
Adolescent
Adult
Aged
Case-Control Studies
Colonic Neoplasms
/ genetics
DNA Glycosylases
/ genetics
Female
Genes, APC
Genes, p53
/ genetics
Genetic Predisposition to Disease
/ genetics
Germ-Line Mutation
High-Throughput Nucleotide Sequencing
Humans
Male
Middle Aged
Mutation
Neoplasm Metastasis
/ genetics
Retrospective Studies
Survival Analysis
Young Adult
Colon cancer
Gene Mutuation
Metastasis
Journal
Asian Pacific journal of cancer prevention : APJCP
ISSN: 2476-762X
Titre abrégé: Asian Pac J Cancer Prev
Pays: Thailand
ID NLM: 101130625
Informations de publication
Date de publication:
01 Dec 2021
01 Dec 2021
Historique:
received:
05
04
2021
entrez:
30
12
2021
pubmed:
31
12
2021
medline:
19
2
2022
Statut:
epublish
Résumé
It is known that many genes are associated with colon cancer. We aimed to investigate the effect of gene mutations on metastasis and overall survival in metastatic and non metastatic colon cancers. A total of 50 patients with metastatic (n=25) and non metastatic (n=25) diagnosed with colon cancer between 2010 and 2018 were included in the study. APC, MUTYH, RAD50, MEN1, ATM, PALB2, NSH2, BRCA1, BRCA2, MLH1, BRIP1, TP53, PTEN, BARD1, MSH6, PMS2, NBN, and FAM175A gene mutations were evaluated using the next generation sequencing method. The effect of gene mutations on metastasis and overall survival were evaluated. The mean age of patients with colon cancer without distant metastasis was 48.64±14.72 years and for patients with distance metases was 56.68±11.65. The mean survival time of colon cancer patients with distant organ metastasis after the metastasis date was 104.36±58.59 weeks. The presence of APC, MUTYH, and TP53 genetic mutations was observed with a higher rate in metastatic colon cancer (p<0.05). We showed that APC, MUTYH, and TP53 mutations are associated with distant organ metastasis.
Identifiants
pubmed: 34967562
doi: 10.31557/APJCP.2021.22.12.3839
pmc: PMC9080374
pii:
doi:
Substances chimiques
DNA Glycosylases
EC 3.2.2.-
mutY adenine glycosylase
EC 3.2.2.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3839-3846Références
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