Impact of Spatially Heterogeneous Trop-2 Expression on Prognosis in Oral Squamous Cell Carcinoma.
Aged
Aged, 80 and over
Antigens, Neoplasm
/ metabolism
Biomarkers, Tumor
/ metabolism
Carcinoma, Squamous Cell
/ metabolism
Cell Adhesion Molecules
/ metabolism
Female
Humans
Immunoconjugates
/ metabolism
Immunohistochemistry
/ methods
Male
Middle Aged
Mouth Mucosa
/ metabolism
Mouth Neoplasms
/ metabolism
Prognosis
TACSTD2
Trop-2
antibody-drug conjugates
biomarker
head and neck cancer
immunohistochemistry
oral squamous cell carcinoma
prognosis
tumor associated calcium signal transducer 2
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
22 Dec 2021
22 Dec 2021
Historique:
received:
05
12
2021
revised:
16
12
2021
accepted:
19
12
2021
entrez:
11
1
2022
pubmed:
12
1
2022
medline:
1
2
2022
Statut:
epublish
Résumé
Oral cancer often presents with aggressive behavior and a high risk of recurrence and metastasis. For oral squamous cell carcinoma (OSCC), which is the most frequent histological subtype, therapy strategies include surgery, radiation therapy, chemotherapy, immune checkpoint inhibitors, and EGFR inhibitors. Recently, a Trop-2 antibody-drug conjugate (ADC) has been approved in the United States of America for the treatment of advanced triple-negative breast cancer. However, this ADC has also been tested in other solid tumors including head & neck squamous cell carcinoma. The prognostic impact of Trop-2 has already been reported for several cancers. We studied the prognostic influence of Trop-2 protein expression on OSCC patients' survival. The cohort comprised
Identifiants
pubmed: 35008509
pii: ijms23010087
doi: 10.3390/ijms23010087
pmc: PMC8745008
pii:
doi:
Substances chimiques
Antigens, Neoplasm
0
Biomarkers, Tumor
0
Cell Adhesion Molecules
0
Immunoconjugates
0
TACSTD2 protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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