Developmental single-cell transcriptomics of hypothalamic POMC neurons reveal the genetic trajectories of multiple neuropeptidergic phenotypes.
POMC
development
developmental biology
hypothalamus
mouse
neuroscience
single-cell transcriptomics
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
19 01 2022
19 01 2022
Historique:
received:
07
08
2021
accepted:
18
01
2022
pubmed:
20
1
2022
medline:
4
3
2022
entrez:
19
1
2022
Statut:
epublish
Résumé
Proopiomelanocortin (POMC) neurons of the hypothalamic arcuate nucleus are essential to regulate food intake and energy balance. However, the ontogenetic transcriptional programs that specify the identity and functioning of these neurons are poorly understood. Here, we use single-cell RNA-sequencing (scRNA-seq) to define the transcriptomes characterizing
Identifiants
pubmed: 35044906
doi: 10.7554/eLife.72883
pii: 72883
pmc: PMC8806186
doi:
pii:
Substances chimiques
Pro-Opiomelanocortin
66796-54-1
Banques de données
GEO
['GSE154153', 'GSE181539']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK020572
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK068400
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK034933
Pays : United States
Informations de copyright
© 2022, Yu et al.
Déclaration de conflit d'intérêts
HY, MR, ML No competing interests declared
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