Silencing of ciliary protein ZMYND10 affects amitotic macronucleus division in Paramecium tetraurelia.

Cell Cycle Cilia Cytoskeletal Proteins Macronucleus Paramecium Paramecium tetraurelia
Macronucleus division Microtubule Paramecium tetraurelia ZMYND10

Journal

European journal of protistology
ISSN: 1618-0429
Titre abrégé: Eur J Protistol
Pays: Germany
ID NLM: 8917383

Informations de publication

Date de publication:
Feb 2022
Historique:
received: 22 06 2021
revised: 29 12 2021
accepted: 31 12 2021
pubmed: 23 1 2022
medline: 16 2 2022
entrez: 22 1 2022
Statut: ppublish

Résumé

Zinc finger MYND-type containing 10 (ZMYND10) or BLU is a putative tumor suppressor that inhibits the proliferation of nasopharyngeal carcinoma cells by regulating the cell cycle. On the other hand, some recent studies have also found that ZMYND10 is a ciliary protein that is essential for ciliary structure and function and is mutated in primary ciliary dyskinesia (PCD). Our recent study shows that ZMYND10 is essential for ciliary growth and structure in Paramecium tetraurelia. The results in the current work continually reveal that depletion of ZMYND10 interrupted the process of amitotic macronucleus division in Paramecium. Immunostaining showed that the microtubular backbone of dividing macronucleus disintegrated in cells without ZMYND10. Furthermore, a transcriptomic analysis and RT-qPCR revealed the differential expression of some genes, including DYHA, DYHB, kinesin, kinesin-like proteins and Ran-GTP in ZMYND10-depleted cells, in accordance with their roles in regulating cilia and macronucleus division.

Identifiants

DOI: 10.1016/j.ejop.2021.125863 PMID: 35065333
pubmed: 35065333
pii: S0932-4739(21)00098-5
doi: 10.1016/j.ejop.2021.125863
pii:
doi:

Substances chimiques

Cytoskeletal Proteins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

125863

Informations de copyright

Copyright © 2022 Elsevier GmbH. All rights reserved.

Auteurs

Lei Shi (L)

School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, PR China. Electronic address: doudou246@163.com.

Yuan Shen (Y)

School of Pharmacy, Xinxiang Medical University, Xinxiang 453003, PR China; Xinxiang Key Laboratory of Clinical Psychopharmacology, Xinxiang 453003, PR China. Electronic address: s.y0001@163.com.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques cellulaires › Cycle cellulaire › Silencing of ciliary protein ZMYND10 affects...
questionsmedicales.fr › Cellules › Structures cellulaires › Prolongements cytoplasmiques › Cils vibratiles › Silencing of ciliary protein ZMYND10 affects...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Silencing of ciliary protein ZMYND10 affects...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Noyau de la cellule › Macronucléus › Silencing of ciliary protein ZMYND10 affects...
questionsmedicales.fr › Eucaryotes › Alveolata › Ciliophora › Oligohymenophorea › Hymenostomatida › Peniculina › Paramecium › Silencing of ciliary protein ZMYND10 affects...
questionsmedicales.fr › Eucaryotes › Alveolata › Ciliophora › Oligohymenophorea › Hymenostomatida › Peniculina › Paramecium › Paramecium tetraurella › Silencing of ciliary protein ZMYND10 affects...