Reagent-Based Scaffold Diversity for DNA-Encoded Library Design: Solid Phase Synthesis of DNA-Tagged sp

DNA / chemical synthesis Gene Library Heterocyclic Compounds / chemistry Molecular Structure Solid-Phase Synthesis Techniques

Journal

Organic letters
ISSN: 1523-7052
Titre abrégé: Org Lett
Pays: United States
ID NLM: 100890393

Informations de publication

Date de publication:
18 02 2022
Historique:
pubmed: 4 2 2022
medline: 25 3 2022
entrez: 3 2 2022
Statut: ppublish

Résumé

Reactions that require strictly dry conditions are challenging to translate to a DNA-encoded library format. Controlled pore glass solid support-connected DNA oligonucleotide-aldehyde conjugates could be condensed with SnAP reagents and cyclized to various sp

Identifiants

DOI: 10.1021/acs.orglett.2c00228 PMID: 35113572
pubmed: 35113572
doi: 10.1021/acs.orglett.2c00228
doi:

Substances chimiques

Heterocyclic Compounds 0
DNA 9007-49-2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1383-1387

Auteurs

Mateja Klika Škopić (MK)

TU Dortmund University, Faculty of Chemistry and Chemical Biology, Medicinal Chemistry, Otto-Hahn-Str. 6, 44227 Dortmund, Germany.

Florian Losch (F)

TU Dortmund University, Faculty of Chemistry and Chemical Biology, Medicinal Chemistry, Otto-Hahn-Str. 6, 44227 Dortmund, Germany.

Angus E McMillan (AE)

Department of Chemistry and Applied Biosciences, ETH Zürich, 8093 Zürich, Switzerland.
ORCID: 0000-0002-8883-1380

Niklas Willeke (N)

TU Dortmund University, Faculty of Chemistry and Chemical Biology, Medicinal Chemistry, Otto-Hahn-Str. 6, 44227 Dortmund, Germany.

Mateo Malenica (M)

TU Dortmund University, Faculty of Chemistry and Chemical Biology, Medicinal Chemistry, Otto-Hahn-Str. 6, 44227 Dortmund, Germany.

Luis Bering (L)

TU Dortmund University, Faculty of Chemistry and Chemical Biology, Medicinal Chemistry, Otto-Hahn-Str. 6, 44227 Dortmund, Germany.

Jeffrey Bode (J)

Department of Chemistry and Applied Biosciences, ETH Zürich, 8093 Zürich, Switzerland.
ORCID: 0000-0001-8394-8910

Andreas Brunschweiger (A)

TU Dortmund University, Faculty of Chemistry and Chemical Biology, Medicinal Chemistry, Otto-Hahn-Str. 6, 44227 Dortmund, Germany.
ORCID: 0000-0002-4401-1495

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Classifications MeSH

questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › Reagent-Based Scaffold Diversity for...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Banque de gènes › Reagent-Based Scaffold Diversity for...
questionsmedicales.fr › Composés hétérocycliques › Reagent-Based Scaffold Diversity for...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Reagent-Based Scaffold Diversity for...
questionsmedicales.fr › Technologie, industrie et agriculture › Technologie › Technologie pharmaceutique › Techniques de chimie synthétique › Techniques de synthèse en phase solide › Reagent-Based Scaffold Diversity for...