Interrogating Glioma-Associated Microglia and Macrophage Dynamics Under CSF-1R Therapy with Multitracer In Vivo PET/MRI.
Acetamides
/ metabolism
Amines
/ metabolism
Amino Acids
/ metabolism
Animals
Brain Neoplasms
/ metabolism
Fluorine Radioisotopes
/ metabolism
Glioma
/ diagnostic imaging
Macrophage Colony-Stimulating Factor
/ metabolism
Macrophages
/ metabolism
Magnetic Resonance Imaging
Mice
Mice, Inbred C57BL
Microglia
/ pathology
Positron Emission Tomography Computed Tomography
Positron-Emission Tomography
Pyrimidines
/ metabolism
Receptor Protein-Tyrosine Kinases
/ metabolism
18F-DPA-714
C57BL/6
CSF-1R
GAMM
TSPO
glioma
Journal
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
ISSN: 1535-5667
Titre abrégé: J Nucl Med
Pays: United States
ID NLM: 0217410
Informations de publication
Date de publication:
09 2022
09 2022
Historique:
received:
06
10
2021
revised:
04
01
2022
pubmed:
5
2
2022
medline:
13
10
2022
entrez:
4
2
2022
Statut:
ppublish
Résumé
Glioma-associated microglia and macrophages (GAMMs) are key players in creating an immunosuppressive microenvironment. They can be efficiently targeted by inhibiting the colony-stimulating factor 1 receptor (CSF-1R). We applied noninvasive PET/CT and PET/MRI using
Identifiants
pubmed: 35115369
pii: jnumed.121.263318
doi: 10.2967/jnumed.121.263318
pmc: PMC9454459
doi:
Substances chimiques
Acetamides
0
Amines
0
Amino Acids
0
Fluorine Radioisotopes
0
Pyrimidines
0
Macrophage Colony-Stimulating Factor
81627-83-0
Receptor Protein-Tyrosine Kinases
EC 2.7.10.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1386-1393Informations de copyright
© 2022 by the Society of Nuclear Medicine and Molecular Imaging.
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