An instructive role for Interleukin-7 receptor α in the development of human B-cell precursor leukemia.

Animals Antigens, CD34 / genetics Base Sequence Cell Differentiation / genetics Cyclin-Dependent Kinase Inhibitor p16 / genetics Gene Expression / immunology Humans Interleukin-7 Receptor alpha Subunit / genetics Mice, Inbred NOD Mice, Knockout Mice, SCID Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / genetics Precursor Cells, B-Lymphoid / immunology RNA-Seq / methods Receptors, Cytokine / genetics Signal Transduction / genetics Single-Cell Analysis / methods Transplantation, Heterologous

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
03 02 2022
Historique:
received: 22 04 2020
accepted: 10 01 2022
entrez: 4 2 2022
pubmed: 5 2 2022
medline: 24 2 2022
Statut: epublish

Résumé

Kinase signaling fuels growth of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Yet its role in leukemia initiation is unclear and has not been shown in primary human hematopoietic cells. We previously described activating mutations in interleukin-7 receptor alpha (IL7RA) in poor-prognosis "ph-like" BCP-ALL. Here we show that expression of activated mutant IL7RA in human CD34

Identifiants

DOI: 10.1038/s41467-022-28218-7 PMID: 35115489 PMC: PMC8814001
pubmed: 35115489
doi: 10.1038/s41467-022-28218-7
pii: 10.1038/s41467-022-28218-7
pmc: PMC8814001
doi:

Substances chimiques

Antigens, CD34 0
CRLF2 protein, human 0
Cyclin-Dependent Kinase Inhibitor p16 0
Interleukin-7 Receptor alpha Subunit 0
Receptors, Cytokine 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

659

Subventions

Organisme : NCI NIH HHS
ID : R01 CA236626
Pays : United States
Organisme : NCI NIH HHS
ID : R37 CA233691
Pays : United States

Informations de copyright

© 2022. The Author(s).

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Auteurs

Ifat Geron (I)

Felsenstein Medical Research Center and The Molecular Genetics and Biochemistry Department, Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel.
Institute of Pediatric Research, Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center, Tel Hashomer, Israel.
The Rina Zaizov Pediatric Hematology and Oncology Division Schneider Children's Medical Center of Israel, Petach Tikva, Israel.

Angela Maria Savino (AM)

Felsenstein Medical Research Center and The Molecular Genetics and Biochemistry Department, Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel.
Institute of Pediatric Research, Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center, Tel Hashomer, Israel.
The Rina Zaizov Pediatric Hematology and Oncology Division Schneider Children's Medical Center of Israel, Petach Tikva, Israel.

Hila Fishman (H)

Felsenstein Medical Research Center and The Molecular Genetics and Biochemistry Department, Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel.
Institute of Pediatric Research, Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center, Tel Hashomer, Israel.
The Rina Zaizov Pediatric Hematology and Oncology Division Schneider Children's Medical Center of Israel, Petach Tikva, Israel.

Noa Tal (N)

Felsenstein Medical Research Center and The Molecular Genetics and Biochemistry Department, Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel.
Institute of Pediatric Research, Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center, Tel Hashomer, Israel.

John Brown (J)

Department of Cancer Biology, UCL Cancer Institute, UCL, London, UK.
ORCID: 0000-0001-7463-3503

Virginia A Turati (VA)

Department of Cancer Biology, UCL Cancer Institute, UCL, London, UK.
ORCID: 0000-0002-1013-9490

Chela James (C)

Department of Cancer Biology, UCL Cancer Institute, UCL, London, UK.

Jolanda Sarno (J)

Department of Pediatrics, Bass Center for Childhood Cancer and Blood Disorders, Stanford University, Stanford, CA, USA.
ORCID: 0000-0003-3488-0248

Michal Hameiri-Grossman (M)

The Rina Zaizov Pediatric Hematology and Oncology Division Schneider Children's Medical Center of Israel, Petach Tikva, Israel.

Yu Nee Lee (YN)

Felsenstein Medical Research Center and The Molecular Genetics and Biochemistry Department, Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel.
Pediatric Department and the Immunology Service, Jeffrey Modell Foundation Center, Edmond and Lily Safra Children's Hospital Sheba Medical Center, Tel-Hashomer, Israel.

Avigail Rein (A)

Felsenstein Medical Research Center and The Molecular Genetics and Biochemistry Department, Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel.
Institute of Pediatric Research, Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center, Tel Hashomer, Israel.
The Rina Zaizov Pediatric Hematology and Oncology Division Schneider Children's Medical Center of Israel, Petach Tikva, Israel.

Hillary Maniriho (H)

Felsenstein Medical Research Center and The Molecular Genetics and Biochemistry Department, Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel.
The Rina Zaizov Pediatric Hematology and Oncology Division Schneider Children's Medical Center of Israel, Petach Tikva, Israel.

Yehudit Birger (Y)

Felsenstein Medical Research Center and The Molecular Genetics and Biochemistry Department, Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel.
Institute of Pediatric Research, Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center, Tel Hashomer, Israel.
The Rina Zaizov Pediatric Hematology and Oncology Division Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
ORCID: 0000-0002-3400-1306

Anna Zemlyansky (A)

The Rina Zaizov Pediatric Hematology and Oncology Division Schneider Children's Medical Center of Israel, Petach Tikva, Israel.

Inna Muler (I)

Institute of Pediatric Research, Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center, Tel Hashomer, Israel.

Kara L Davis (KL)

Department of Pediatrics, Bass Center for Childhood Cancer and Blood Disorders, Stanford University, Stanford, CA, USA.
ORCID: 0000-0002-7182-2592

Victoria Marcu-Malina (V)

Cytogenetic Unit laboratory of Hematology, Chaim Sheba Medical Center Tel Hashomer, Tel Hashomer, Israel.

Nicole Mattson (N)

Department of Systems Biology, City of Hope Comprehensive Cancer Center, Monrovia, CA, USA.

Oren Parnas (O)

The Concern Foundation Laboratories at the Lautenberg Center for immunology and Cancer Research, IMRIC, Hebrew University Faculty of Medicine, Jerusalem, Israel.
ORCID: 0000-0002-2714-9011

Rabea Wagener (R)

Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children's Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.

Ute Fischer (U)

Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children's Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
ORCID: 0000-0002-2455-2489

João T Barata (JT)

Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
ORCID: 0000-0002-4826-8976

Catriona H M Jamieson (CHM)

UC San Diego, Moores Cancer Center, Division of Regenerative Medicine, Department of Medicine and Sanford Stem Cell Clinical Center, Ja Jolla, CA, USA.

Markus Müschen (M)

Department of Systems Biology, City of Hope Comprehensive Cancer Center, Monrovia, CA, USA.
ORCID: 0000-0002-6064-8613

Chun-Wei Chen (CW)

Department of Systems Biology, City of Hope Comprehensive Cancer Center, Monrovia, CA, USA.
ORCID: 0000-0002-8737-6830

Arndt Borkhardt (A)

Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children's Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
ORCID: 0000-0002-6121-4737

Ilan Richard Kirsch (IR)

Adaptive Biotechnologies, Inc., Seattle, WA, USA.

Arnon Nagler (A)

Felsenstein Medical Research Center and The Molecular Genetics and Biochemistry Department, Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel.
Hematology Division BMT and Cord Blood Bank Chaim Sheba Medical Center Tel-Hashomer, Tel-Hashomer, Israel.

Tariq Enver (T)

Department of Cancer Biology, UCL Cancer Institute, UCL, London, UK.
ORCID: 0000-0002-0866-6443

Shai Izraeli (S)

Felsenstein Medical Research Center and The Molecular Genetics and Biochemistry Department, Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel. sizraeli@gmail.com.
Institute of Pediatric Research, Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center, Tel Hashomer, Israel. sizraeli@gmail.com.
The Rina Zaizov Pediatric Hematology and Oncology Division Schneider Children's Medical Center of Israel, Petach Tikva, Israel. sizraeli@gmail.com.
Department of Systems Biology, City of Hope Comprehensive Cancer Center, Monrovia, CA, USA. sizraeli@gmail.com.
ORCID: 0000-0002-6938-2540

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › An instructive role for Interleukin-7 receptor...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes CD › Antigènes CD34 › An instructive role for Interleukin-7 receptor...
questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence nucléotidique › An instructive role for Interleukin-7 receptor...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › An instructive role for Interleukin-7 receptor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines suppresseurs de tumeurs › Protéines inhibitrices des kinases cyclines-dépendantes › Inhibiteur p16 de kinase cycline-dépendante › An instructive role for Interleukin-7 receptor...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › An instructive role for Interleukin-7 receptor...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › An instructive role for Interleukin-7 receptor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux cytokines › Récepteurs aux interleukines › Récepteurs à l'interleukine-7 › Sous-unité alpha du récepteur à l'interleukine-7 › An instructive role for Interleukin-7 receptor...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée NOD › An instructive role for Interleukin-7 receptor...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › An instructive role for Interleukin-7 receptor...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souches mutantes de souris › Souris SCID › An instructive role for Interleukin-7 receptor...
questionsmedicales.fr › Maladies du système immunitaire › Syndromes immunoprolifératifs › Syndromes lymphoprolifératifs › Leucémie lymphoïde › Leucémie-lymphome lymphoblastique à précurseurs B et T › Leucémie-lymphome lymphoblastique à précurseurs B › An instructive role for Interleukin-7 receptor...
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